ResourceDrug Discovery & Development
From macro to micro: A leap in small molecule sensitivity
22 Oct 2026This application note explores the use of biolayer interferometry (BLI) for real-time analysis of small-molecule binding interactions, an area traditionally associated with surface plasmon resonance (SPR). Learn how the binding kinetics and affinities of sulfonamide-based inhibitors to carbonic anhydrase II were characterized using the Octet® R8e platform. Discover how enhanced BLI sensitivity can support reliable detection of strong and weak interactions, provide deeper insight into structure-function relationships, and expand the use of label-free kinetic analysis in small-molecule drug discovery.
Resource details:
Resource type: Application note
Page count: 7
Read time: 6 mins
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Drug DeliveryDrug Delivery refers to dosage form, route of administration, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Drug delivery is often approached via the biopharmaceutical or small molecule drug's formulation, but it may also involve medical devices or drug-device combination products. Considerations include instrumentation, software and services. AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Biophysical Characterization