A streamlined CGE-UV workflow for high-resolution analysis of single-stranded oligonucleotides up to 200+ nt
21 Oct 2026As oligonucleotide therapeutics become more complex, reliable purity, integrity, and sizing analysis is essential for distinguishing closely related species and supporting confident characterization. Longer sequences can make achieving consistent resolution and transferring methods from development into quality control particularly challenging.
Discover how the SCIEX Oligo 200 nt Purity and Integrity kit simplifies analysis using capillary gel electrophoresis with ultraviolet detection (CGE-UV). Covering 10 to 200+ nucleotides with single-nucleotide resolution up to 141 nucleotides, the ready-to-use workflow reduces preparation and supports reproducible performance. This means laboratories can confidently characterize increasingly complex oligonucleotides while simplifying method transfer from development to quality control.
Resource details:
Resource type: Application note
Page count: 11
Read time: 10 mins
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