Drug discovery > Lead Discovery Products & Reviews

16S/18S/ITS rRNA amplicon metagenomic sequencing employs universal primers to target specific regions to identify the phylogeny and taxonomy from complex microbiomes.

Single cell RNA sequencing uncovers the complexity of cellular diversity to employ the study of unusual cell types, cell-lineage associations, and samples of heterogeneous nature with 10x Genomics technology.

Long Read Sequencing (LRS) service employs cutting-edge technologies such as Oxford Nanopore and PacBio platforms for decoding complex genomes, completing transcriptomes, exploring metagenomes, and investigating structural variations with unmatched precision.  

Whole exome sequencing allows for sequencing human and mouse exomes in an array of panel options, which facilitates research contexts and clinical contexts.

The ecTOF is the world’s first GC-HRMS with simultaneous acquisition of EI (Electron Ionization) and CI (Chemical Ionization) information in a single injection. While using EI as the gold-standard GC/MS ionization, the ecTOF in parallel operates a novel CI source. This way it simultaneously provides perfectly aligned accurate mass structural and molecular ion information within a single GC run.

The Rapid_pH™ Automated 96 pH meter automates the pH measurements of samples in a 96 well format. The Rapid_pH allows samples to be processed in a fraction of the time compared to manual methods avoiding errors in both measurement and data registration. Full automation for well plates and other arrayed containers provides unattended runs and walk-away time.

Accelerate precision oncology with Crown Bioscience’s high-quality human biospecimens—comprehensive, clinically annotated samples including tumor tissue, plasma, and PBMCs, optimized for multi-omics research and biomarker discovery.

ARRALYZE 8 Chamber Slide combines standard slide format with advanced nanowell technology, featuring 8 chambers with 127 precisely etched nanowells (0.4 × 0.4 × 0.225mm) per chamber. The borosilicate glass bottom (0.175μm thick under wells) provides superior optical clarity for high-resolution imaging while maintaining an inert environment. Includes 3 fiducials per chamber for easy navigation and precise cell tracking.

A compact benchtop design that incorporates 2 or 10 individually powered, high-output stirring stations which can prepare samples for content uniformity testing up to 90% faster than conventional methods.​

Simplify your omics research

Rainbow is an in-situ, fiber optic probe-based, concentration monitor that measures concentration and changes in concentration in real-time without the need for sampling.

Prep your samples, dry them on your LazWell plate, stack ‘em in the Luxon and start it. Best part is, there are virtually no false positives when using the LDTD technology, so it’s the perfect alternative to your EIA high-throughput screening methods. Wanna do it even faster? With our Luxon-HTS model, you can go below 1 second per sample. Talk about high-speed analysis!

Cell Line-Derived Xenograft Models, Established multiple in vivo assay systems to evaluate novel anticancer compounds, with each assay specifically designed to understand a drug's mechanism of action, or an individual agent property.

Sirius T3 measures pKa, log P, and the solubility of ionizable drugs and small molecules using sub-milligram quantities of samples.

OpenSPR® provides real-time, label-free SPR data at a fraction of the cost of existing solutions. Highly sensitive while being simple to maintain and operate, OpenSPR has been used by hundreds of researchers to generate publication-quality data.

CrownSyn™: Quantify and visualize drug synergy, antagonism, or additivity in vitro and in vivo with Crown Bioscience’s robust bioinformatics platform—empowering oncology researchers to optimize combination therapies with confidence.

Machine-learning software that reduces the analysis bottleneck of large data sets in your surface plasmon resonance workflow

Delve into biomarker discovery and drug development with Crown Bioscience’s next-generation proteomics services—leveraging 4D-DIA technology for deep, reproducible protein profiling and post-translational modification analysis.

Unlock immune insights with Crown Bioscience’s high-throughput flow cytometry—precisely characterize immune cell populations across tissues to elucidate drug mechanisms, assess pharmacodynamics, and optimize immunotherapies.

The new standard of excellence in quantitative metabolomics profiling

Pion’s PAMPA high-throughput permeability assay uses a range of membranes to mimic physiologic conditions. It allows you to evaluate the passive permeability of API’s as well as the absorption potential of simple or complex formulations using robust models and protocols in a 96-well format.

Accelerate the development of your immuno-oncology drugs with Crown Bioscience’s large panel of immunocompetent syngeneic models.

Crown Bioscience’s preclinical biomarker services help identify, validate, and analyze biomarkers across diverse in vitro and in vivo cancer models. Using multi-omics platforms and expert bioinformatics, these services support drug mechanism studies, patient stratification, and companion diagnostic development to guide oncology drug discovery.

Unraveling the complexity of disease

PDX Models Empower your research with models that reflect today’s patients and treatments.