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Single-Domain Antibody Libraries

Twist Biopharma, a division of Twist Bioscience, provides services to help accelerate the way our partners discover and optimize antibody therapeutics with our unique DNA writing technology. Twist constructs proprietary antibody libraries precisely designed to match sequences that occur in the human body giving our partners an integral and unbiased resource for antibody therapeutic discovery and optimization.

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Twist uses four novel VHH methods that combine synthetic and natural approaches to maximize diversity, creating highquality VHH libraries for use against any protein target. These proprietary, naïve single chain domain libraries are ideal for initiating antibody discovery and development. Their modular nature supports creation of bi- or multi-specific antibodies ideal for developing next generation therapies.

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