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Twist Universal Blockers

Twist Biosciencemethylation, genome

A single blocking solution for multiple adapter applications

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In targeted next-generation sequencing (NGS), a blocking solution is used during probe hybridization to prevent non-specific hybridization between target enrichment probes and adapter sequences. Twist Universal blockers are designed to block multiple TruSeq-compatible barcode sequences and adapter lengths. They can accommodate multiple projects and applications, eliminating the need to purchase multiple blocker products for TruSeq-compatible adapters with varied index designs.


Flexible Blocking Solution

  • No need for adapter-specific blockers — blocks many different adapter designs
  • Effective across singleplex and multiplex target enrichment workflows
  • Improves on-target capture regardless of panel size

Improved On-Target Capture

  • Prevents cross-hybridization between TruSeq-compatible adapters
  • Enhances the performance of target enrichment workflows

Maximized Efficiency

  • Ready-to-use formulation
  • Reduces per-sample sequencing cost

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