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Twist Synthetic SARS-CoV-2 RNA Controls

Positive controls provide quality control measures for the verification and validation for point-of-care diagnostic tests including both next-generation sequencing (NGS) and reverse transcriptase-polymerase chain reaction (RT-PCR) assays. Twist offers fully synthetic SARS-CoV-2 RNA controls, available for dozens of distinct reference sequences.

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Twist Bioscience

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Average Rating 4.9

|5Scientists have reviewed this product

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Great service. High quality product.


Average Rating 5.0

Application Area:


High quality product. Twist provides the most current SARS-CoV-2 variant controls. The process from getting a quote to shipping and delivery is exceptional and timely.

Review Date: 9 Feb 2023 | Twist Bioscience

These RNA controls are easy to use and offer reproducible results.


Average Rating 4.7

Application Area:

Assay quality assurance

Twist offers a wide range of synthetic RNA controls, which are easy to use and offer reproducible results. They are great for making sure our assays work as intended. Also, the products have always been delivered really fast after order. Nothing negative to say about these products!

Review Date: 17 Oct 2022 | Twist Bioscience

Very good source of control RNA


Average Rating 4.7

Application Area:

Control RNA for identifying potential RNA modifications

The RNA is high quality and was far more convenient than in vitro transcription of the entire viral gRNA.

Review Date: 18 Mar 2022 | Twist Bioscience

The MVP of 2020 SARS-CoV-2assay development!


Average Rating 5.0

Application Area:

Assay development

This product is simple to use, simple to buy, and excellently packaged and orderable. Customer support answered all questions fully and quickly and was a very easy process. This is one of the most straight forward companies I have had to deal with and was the easiest and most important material I had to routinely buy during 2020. Materials always shipped same or next day and were received the next business day. Our team would not have been able to develop and perfect our SARS-CoV-2 assays without this material.

Review Date: 16 May 2021 | Twist Bioscience

I really like everything about Twist Bioscience.


Average Rating 5.0

Application Area:

Develop COVID-19 Assay Microfluidic Platform, Use it as a Standard Control

Both the customer service and the products have greatly met my expectation. The product is professional and people are great and helpful.

Review Date: 11 May 2021 | Twist Bioscience

Twist has created synthetic RNA controls for several viral genomes, and variants were selected to cover a wide range of sequence diversity. Each control consists of six non-overlapping 5 kb fragments generated from Twist Gene Fragments then transcribed into ssRNA. These controls provide coverage of greater than 99.9% of the bases of the SARS-CoV-2 viral genome. The majority of the controls are provided in the standard format which consist of 100 μL at a concentration of approximately one million copies per microliter. Twist also offers certain controls in Assay Ready and Encapsulated Formats that are supplied as a desiccated pellet. The Assay Ready Controls are supplied at approximately two million copies per tube. The Encapsulated Controls are supplied at approximately 50,000 copies per tube.

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