Olink Explore® 384 Neurology by Olink Proteomics
Olink® Explore 384 Neurology is a high-multiplex, high-throughput protein biomarker platform that uses Proximity Extension Assay (PEA) technology coupled to an innovative new readout methodology based on Next Generation Sequencing (NGS) using the Illumina® NovaSeq instrument.
PEA uses matched pairs of antibodies (Abs) attached to unique DNA oligonucleotides. When the correct pair simultaneously binds to a target protein, their DNA oligonucleotides hybridize and serve as a unique template for DNA polymerase-dependent extension. This provides a double-stranded DNA molecule for each detected protein, providing a unique barcode for high-sensitivity, high-specificity readout. The well-established Olink Target 96-panels use qPCR for the readout step, but marrying our elegant PEA technology with NGS for readout in Olink Explore provides several advantages:
- Simultaneous analysis of 384 protein biomarkers
- Use just 1 µL of biological sample
- All assays subject to Olink’s strict technical validation and quality control procedures.
- NGS readout
- Higher throughput compared to our Olink Target 96 & 48 products
- Similar accuracy and precision compared to our standard Target 96-plex and 48-plex products with qPCR readout
- This high level of multiplexing is achieved without any compromise on data quality, thanks to our proprietary PEA technology
Product Overview
Olink Explore® 384 Neurology
Manufacturer Olink Proteomics | Available Worldwide
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