Nexera UC
Supercritical Fluid Extraction/Chromatograph System.
Receive your quote directly from the manufacturer.
Easy to use and very efficient.
Chromatography
Great product. Super easy to use. Super efficient and consistent flow rate. Very reliable.
Review Date: 8 Feb 2021 | Shimadzu Corporation
Overall good product.
Chromatography
High performance HPLC and SFC system. Works well for our needs. Post sales support is difficult to get help from or service.
Review Date: 2 Feb 2021 | Shimadzu Corporation
Advanced chromatographic analysis and high sensitivity detection
study of proteomes and their functions
For cleaning validation which is performed in the pharmaceutical industry to confirm that manufacturing equipment has been properly cleaned
Review Date: 13 Apr 2016 | Shimadzu Corporation
very reliable
biopharmaceuticals
very reliable monitoring of contaminants in cleaning validation
Review Date: 30 Mar 2016 | Shimadzu Corporation
Engineering Considerations Allows for Ease of Use, Early Productivity
Environmental
Great union of SFE and SFC capabilities with minimal additional hardware compared to an LCMS. The ease of use allowed myself, a skilled chromatographer but not accustomed to SFC, to be able to generate enough data for multiple abstracts for the American Society for Mass Spectrometry conference by the end of January.
Review Date: 30 Mar 2016 | Shimadzu Corporation
The world’s first-ever unified and fully automated instrument combining supercritical fluid extraction (SFE) with supercritical fluid chromatography (SFC).
Shimadzu has released its new Nexera UC unified chromatography system. It is the world’s first-ever unified and fully automated instrument combining supercritical fluid extraction (SFE) with supercritical fluid chromatography (SFC). The SFE/SFC/MS platform merges quick and easy online sample preparation with advanced chromatographic analysis and high sensitivity detection. The Nexera UC serves a wide range of applications, e.g. monitoring of pesticides in food products, additives in polymers, drug discovery in pharmaceuticals and biopharmaceuticals and environmental controls or cleaning validation to name just a few.
Increasing speed and efficiency while reducing the risk of human error in the analytical workflow.
The Nexera UC online SFE-SFC approach eliminates the need for tedious, manual sample pretreatment. All samples are extracted under light-shielding, anaerobic conditions, enabling highly reproducible analysis even of unstable compounds that are easily oxidized or degraded using a conventional liquid extraction method. Notably, analysis of pesticides in food products, with the state-of-the-art Nexera UC system and sample preparation in the SFE unit takes just a fraction of the time needed using the traditional QuEChERS method. Furthermore, the fully automated Nexera UC system offers much higher recovery rates of target analytes while significantly reducing the risk of human error during sample pretreatment.
Nexera UC provides hassle-free, highly efficient sample extraction of up to 48 samples with easy on-line transfer to chromatographic separation and MS/MS detection. The system achieves the highest levels of sensitivity due to splitless injection of the entire eluent volume.
”Green” chromatography.
The innovative Nexera UC system offers a supplementary chromatographic technique to conventional LC and GC analysis that enables separation of an even wider range of non-polar to very polar analytes. Automated extraction and chromatography are achieved using a mobile phase of supercritical carbon dioxide, which exhibits the solubility of a liquid with the diffusivity of a gas. Solvent strength can be increased by adding a polar co-solvent. SFE and SFC are therefore faster, more efficient, cheaper and more environmentally friendly than other methods using large amounts of toxic organic solvents.
Features:
- Very fast separation speed due to the relatively low viscosity of supercritical fluid
- Improved peak capacity and chromatographic resolution
- Efficient separation of analogues and/or chiral compounds by high penetration mobile phase
- Different separation mode leads to high sensitivity
- Improved sensitivity resulting from split-less introduction into detector
- Reduction of environmental impacts and costs by reducing amount of organic solvents needed
Evaluating the performance of the LotusStream Gas-Liquid Separator for preparative supercritical fluid chromatography
In this application note, Shimadzu evaluates the performance of the LotusStream Gas-Liquid Separator for preparative supercritical fluid chromatography.
Analysis of 9 cannabinoids by supercritical fluid chromatography
In this application note, Shimadzu demonstrates the use of supercritical fluid chromatography to quantitate nine cannabinoids in hemp flower. This method exhibits an alternative selectivity to reversed-phase HPLC (RP-HPLC) and can generally be considered a green technique.
Perchlorate quantitation in drinking water using suppressed anion chromatography coupled with single quadrupole MS
In this application note, Shimadzu develops an IC-MS method using a novel electrolytically regenerated anion suppressor as a part of a modular IC system coupled with a LCMS 2020 single quadrupole MS to achieve higher sensitivity and selectivity for perchlorate determination in drinking water.
Automated Analysis of Explosives in Soil Samples
There are a large number of explosives-contaminated sites in the US, Europe, and Asia. High levels of explosives in soil can threaten the health of humans, livestock, and wildlife. A number of remediation efforts are underway, which require the analysis of explosives in soil samples. Recently, a new technique was introduced the allows the automated supercritical extraction and SFC analysis of samples with minimal sample preparation and handling requirements to save analyst time and sample preparation expenses. This technique was applied to the analysis of explosives in soil samples and showed good recoveries of the explosives tested in a number of different soil samples. Automated analysis of up to 48 samples is possible without the need for manual sample preparation to allow quick screening of explosives in numerous soil samples.
SPE and SFC: A New Standard in Analytical Workflow Design
Current analytical methodology typically consists of a separate off-line sample preparation technique that is followed by a chromatographic analysis. Sample preparation and manual transfer to the analytical instrument often consumes a majority of the analyst's time and effort. This poster explains a new technique that automates the sample preparation and analysis of samples by supercritical fluid extraction of compounds from the sample matrix, which are then transported to the analytical column for analysis without any human intervention.
Analysis of Cortisone Acetate Tablets by Nexera UC SFC System
The United States Pharmacopeia (USP) monographs are widely referenced to ensure the quality of drug substances. The USP monographs offer reliable and robust methods, but some methods, especially those using normal phase HPLC, require harmful solvents. This application note shows an example of the analysis of cortisone acetate tablets according to the USP monograph, using Shimadzu’s Nexera UC SFC system. Nexera UC can improve analytical workflow by utilizing a completely new separation technology, Unified Chromatography, which unites sample separation, analysis with various separation modes, and high-sensitivity detection.
Pfizer drives cancer research breakthroughs with supercritical fluid chromatography
Supercritical fluid chromatography (SFC) is a separation technique that uses a supercritical fluid (most commonly carbon dioxide) as the mobile phase to efficiently purify compounds, offering faster processing, lower solvent consumption, and a more environmentally friendly alternative to traditional liquid chromatography (LC) methods. In this SelectScience interview, Jeff Elleraas, Principal Scientist at Pfizer’s Global Research and Development in La Jolla, California, shares insights into the role of SFC and how machine learning and AI are transforming chiral separations. Plus, discover Pfizer’s mission to tackle the toughest challenges in oncology research, accelerate medicinal chemistry innovations, and create greener, more efficient processes for developing novel cancer treatments.
Find out more information on Nexera UC here.
Discover A SFE/SFC Solution for Sensitive and Reliable Analysis with Minimal Sample Preparation
Watch this video to learn more about the Nexera UC Supercritical Fluid extraction and analysis system from Shimadzu Europa GmbH. Supercritical fluid allows unparalleled waste-minimal sample extraction and analysis, with less toxic solvents and more sensitive detection. The Nexera UC system is ideal for contaminants analysis in the food industry, allowing residual pesticides to be quantified with high resolution.
Improve Your Analytical Workflow with the Nexera UC
Watch this video to see how the Nexera UC Supercritical Fluid Extraction/Chromatograph System can improve your analytical workflow by utilizing a completely new separation technology.
Shimadzu introduces Nexera IC Ion Chromatograph for water quality testing
Engineered for both routine and regulated samples, the Nexera IC combines advanced automation, intuitive software and a space-saving design
New AOC-30 Series automatic sample injection system: Extending the need for next-generation laboratories
The new system supports remote operability for laboratory processes
Shimadzu's new preparative chromatography systems promises high-performance purification
The Nexera Prep HPLC series and Nexera UC Prep are designed to address the challenges of pharmaceutical industries
Product Highlights from HPLC 2015
SelectScience attended this year's HPLC show to bring you the latest advances in high performance liquid chromatography.
