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Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System

Shimadzu Corporation
16 Mar 2015
Kathryn Rix
Administrator / Office Personnel

Product news

The fully automated supercritical fluidic chromatography-based Nexera Unified Chromatography system (Nexera UC) can sequentially analyze up to 48 samples utilizing automatic extraction and chromatographic separation combined with high-sensitivity detection of targets by mass spectrometry.

The Nexera UC system is designed to fulfil the measurement requirements of a wide range of applications including, monitoring pesticides in food products; drug delivery and search for disease biomarkers; additives in forming polymers; drug discovery research in pharmaceuticals and biopharmaceuticals along with cleaning validation.

Speed and efficiency while reducing human errors in the analysis workflow

The Nexera UC system eliminates the need for complicated sample pre-treatment and enables highly reliable and stable analysis of delicate samples that are prone to oxidation or dissociation if exposed to air. Notably, in the analysis of pesticides in food products, the state-of-the-art Nexera UC system takes only five minutes for a complete analysis sample pre-treatment when compared with at least 35 minutes for conventional systems. Furthermore, the fully automated Nexera UC system has a much higher target analyte recovery rate and reduces the possibility of human error during analysis when compared to conventional manual systems.

Nexera UC system highlight

World's first-ever unified and fully automated system that combines supercritical fluidic extraction (SFE) with supercritical fluid chromatography (SFC)

Industry-leading sample throughput for supercritical fluid extraction, enabling up to 48 samples to be continuously and automatically processed

Achieves the highest levels of sensitivity by injecting the entire volume of eluent

Details

The innovative Nexera UC system offers a wide range of separation modes, enabling the separation of a diverse wide range of compounds at once, which is not possible with single systems that are based on gas and liquid chromatography. The automated extraction and chromatography is achieved using a mobile phase of supercritical fluidic Carbon Dioxide (that exhibits the solubility of liquids and diffusivity of gases) into which alcohol and other such organic solvents are added.

Notably, the supercritical fluid chromatography Nexera UC system has the remarkable capability of high-sensitivity analysis of approximately 500 different types of pesticides in less than one hour, thereby shortening the analysis time considerably as compared to conventional chromatography systems.

The Nexera UC system is environmentally "green" as it significantly reduces the quantity of organic solvents used for such applications as the chiral analysis of enantiomers that are common in pharmaceutical drugs.

The Nexera UC system was developed in collaboration between Shimadzu Corporation, Osaka University, Kobe University and Miyazaki Agricultural Research Institute, which is funded by the Japan Science and Technology Agency (JST).

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Supercritical Fluid ChromatographySupercritical Fluid Chromatography (SFC) is used for the rapid separation and analysis of complex mixtures. SFC systems require injectors, pumps, columns, ovens and detectors. The SFC retention method uses a supercritical fluid, usually CO2. There are a number of different SFC detector types including UV / VIs, ECD, mass spectrometry and fluorescence.PesticidesPesticides are used to protect crops from diseases, pests and unwanted plants. They are classed as persistent organic pollutants (POPs) and can be harmful to humans. The Environmental Protection Agency (EPA) currently regulates the use of pesticides in the USA. BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Food TestingFood testing refers to a variety experiments including PCR, mass spectrometry, processing, QuEChERS, analyzing and Kjeldahl.PolymersPolymers are large molecules made up of many repeat units. Natural polymers such as DNA and proteins are essential to life, whereas synthetic polymers such as polystyrene and polyethylene are used widely due to their functionality. Typical techniques for analysis include GPC, SEC, DSC, FT-IR and NMR.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.

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