MicroCal PEAQ-ITC by Malvern Panalytical

Manufacturer Malvern Panalytical  |  Available Worldwide
4.8
/
5.0
  |  3 reviews
Designed for ease-of use and exceptional sensitivity


MicroCal PEAQ-ITC by Malvern Panalytical product image
MicroCal PEAQ-ITC
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Average Rating: 4.8
3 Scientists have reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2019

  • Organization: Concept Life Sciences



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Excellent upgrade of both software and hardware. Maintenance is so much easier!
Rating: 5.0

  • Application Area: Drug discovery

"The MicroCal PEAQ-ITC is a significant upgrade from the VP-ITC and ITC200 in terms of the ease of maintenance. All washing steps are now automated and easy to perform. We find this helps to keep the instrument in an excellent condition even with multiple users. Due to the somewhat complicated cleaning procedures of previous versions of the ITC we found that routine maintenance was not always performed which greatly affected results in this highly sensitive instrument. The PEAQ is still a low volume isothermal titration calorimeter ideal for label-free, in-solution studies of biomolecular interactions. Software upgrades have also made the PEAQ easy to use even for the most inexperienced scientists in the lab, including help in experimental planning and optimisation of parameters prior to performing any runs. We find the PEAQ really useful for confirming binding, measuring stoichiometry, protein QC, troubleshooting other biophysical methods and identifying different mechanisms of binding in closely related compounds."

Review date: 05 Jul 2019 | MicroCal PEAQ-ITC
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Boise State University



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Great instrument!
Rating: 4.3

  • Application Area:Protein/protein interactions; protein/small molecule interactions; protein/nucleic acid interactions

"Excellent ease-of-use. Video training modules allow for users across disciplines to rapidly collect data."

Review date: 05 Jul 2019 | MicroCal PEAQ-ITC

Manufacturer's Response

Thank you Lisa for your review. We are very happy to hear that you like the ‘in-built’ videos. We have had lots of feedback that we shouldn’t expect all our users to be experts or to use the instruments frequently. We have hoped that these videos would allow people to walk up to the instrument and use it straight away without much training.
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: California Lutheran University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
This is a bread and butter instrument for our lab.
Rating: 5.0

  • Application Area:Protein-substrate binding and kinetics

"There is a higher upfront cost than with other ITCs, but the available nascent kinetics parameters and lower cost consumables make it a good investment in the longer term."

Review date: 31 Jan 2017 | MicroCal PEAQ-ITC

Manufacturer's Response

Thank you very much for your feedback.

The MicroCal PEAQ-ITC is a highly sensitive, low volume isothermal titration calorimeter for the label-free in solution study of biomolecular interactions. It delivers direct measurement of all binding parameters in a single experiment and can analyze weak to high affinity binders, using as little as 10µg sample. Semi-automated maintenance minimizes operator intervention and the system is upgradable to the fully automated MicroCal Auto-iTC200, making it ideal for laboratories where speed, sensitivity and the ability to accommodate higher workloads in the future are paramount.


Features:

  • User-friendly guided workflows with embedded help videos give any level of user the ability to generate high quality data.
  • High signal to noise gives more confidence in accessing data quality and relevance of generated affinity and thermodynamic parameters.
  • Automated washing with detergent of the sample cell and titration syringe assists in producing high quality reproducible data.
  • All binding parameters (affinity, stoichiometry, enthalpy and entropy) in a single experiment.
  • Quick to first results with no assay development, no labeling, no immobilization and no molecular weight limitations.
  • Sensitivity to investigate any biomolecular interaction using as little as 10µg of protein.
  • Directly measures millimolar to nanomolar affinities (KDS) (10-2 to 10-9 M).
  • Measures nanomolar to picomolar disassociation constants using competitive binding techniques (10-9 to 10-12M).
  • Nonreactive Hastelloy for chemical resistance and compatibility with biological samples.
  • Compatible with non-aqueous solvents.
  • Upgradable to fully automated MicroCal PEAQ-ITC Automated.

Product Overview

MicroCal PEAQ-ITC by Malvern Panalytical product image

MicroCal PEAQ-ITC

Manufacturer Malvern Panalytical  |  Available Worldwide

4.8 / 5.0 | 3 reviews