MACS GMP T Cell TransAct by Miltenyi Biotec B.V. & Co. KG

MACS^® GMP T Cell TransAct™ is a ready-to-use reagent for efficient in vitro activation and expansion of human T cells. Also available in research grade.

Cell activation is a prerequisite for the successful genetic engineering of T cells. MACS GMP T Cell TransAct from Miltenyi Biotec – with its unique features – enables in vitro stimulation, activation, and expansion of human T cells from hematological cell populations (e.g. PBMCs). Polyclonal T cell expansion can be used in numerous applications including cellular therapy or whenever T cells are activated to improve gene modification.  

Benefits of MACS GMP T Cell TransAct are:

•  Innovative format: A colloidal polymeric nanomatrix conjugated to humanized, recombinant CD3 and CD28 agonists.
•  Ease of use: Effective activation for a large range of cell densities.
•  Convenience: Excess reagent is simply washed off.
•  Safety: Biodegradable, ready to use and compatible with the automated, functionally-closed CliniMACS Prodigy® System. 

Due to the nanoscale structure of MACS GMP T Cell TransAct, the reagent can be sterile filtered. Excess reagent can be removed by simple supernatant replacement. The reagent is finely tuned to work best in combination with TexMACS™ GMP Medium. MACS GMP T Cell TransAct is suitable for the use in automated cell manufacturing systems, such as the CliniMACS Prodigy.

In the US, MACS GMP T Cell TransAct is for use under an approved IND.