Lead Discovery Services by BellBrook Labs

We will work closely with you to define the specific parameters that are important for your lead discovery program and implement the most efficient and cost effective assays and/or kinetic analyses.

Lead Discovery Services Include:

• Inhibitor Screening – to identify or confirm activity with target
• Inhibitor Potency Profiling – dose response with target and/or related proteins
• Residence Time Measurements – determination of koff using ‘jump dilution’ enzymatic assay method
• Mechanism of Action Studies – kinetic analysis to define mode of inhibition
• Inhibitor Selectivity Profiling

Example Targets:

• Protein Kinases
• Lipid Kinases
• Carbohydrate Kinases
• ATPases
• Methyltransferases
• Acetyltransferases
• HDACs
• GTPases, GAPs, GEFs
• Phosphodiesterases
• Helicases
• Ligases/Synthetases
• Glycosyltransferases