Cell-free DNA ScreenTape Analysis
Cell-free DNA ScreenTape analysis provides fast, automated, and reliable electrophoresis of input cell-free DNA (cfDNA) samples.
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Cell-free DNA ScreenTape analysis provides fast, automated, and reliable electrophoresis of input cell-free DNA (cfDNA) samples. The Cell-free DNA ScreenTape assay for TapeStation systems provides accurate sizing and quantification of cfDNA, as well as DNA quality assessment with the objective %cfDNA quality metric. The %cfDNA score automatically provides the percentage of cfDNA in the sample of interest compared to genomic DNA contamination - essential for cell-free DNA integrity analysis in Next Generation Sequencing (NGS) library quality control (QC) and for generating reliable NGS results.
The assay is compatible with the Agilent 4150 and 4200 TapeStation instruments for automated electrophoresis.
For Research Use Only. Not for use in diagnostic procedures. PR7001-4476
Pre-Analytical Considerations for Minimal Residual Disease Detection by Next-Generation Sequencing
For liquid biopsy applications, high recovery of total cfDNA is essential for the detection of ctDNA. Due to requisite low limits of detection, accurate tumor-informed minimum residual disease (MRD) detection by next-generation sequencing (NGS) testing is highly dependent upon maximum recovery of cfDNA from plasma. Conventional cfDNA extraction methods, often subsequently adapted to liquid biopsy applications, fail to deliver sufficient yield or the analytical sensitivity required for early detection of liquid biopsy markers, resulting in assay failure (e.g. ‘QNS errors’).
In this webinar, experts from Strata Oncology will highlight the importance of cfDNA yield and purity using the Revolution Sample Prep System from nRichDx for cfDNA extraction as well as reliable pre-analytical quality control with the Agilent Cell-free DNA ScreenTape assay and the TapeStation systems, and their relation to NGS-based MRD testing.
Key learning objectives
- Learn how to gain high recovery of total cfDNA in liquid biopsy applications such as accurate tumor-informed minimum residual disease by NGS testing
- Discover the importance of high cfDNA yield and purity during cfDNA extraction
- Explore how to ensure pre-analytical quality control of cfDNA samples
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
