GPCR Libraries by Twist Bioscience

Manufacturer Twist Bioscience  |   Model: genetic engineering,
Twist Biopharma, a division of Twist Bioscience, provides services to help accelerate the way our partners discover and optimize antibody therapeutics with our unique DNA writing technology. Twist constructs proprietary antibody libraries precisely designed to match sequences that occur in the human body giving our partners an integral and unbiased resource for antibody therapeutic discovery and optimization.


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GPCR Libraries
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> 100,000 Different GPCR Binding Motifs

With over 100,000 different GPCR binding motifs, unlock the discovery of antibodies to this difficult-to-target class.
 
GPCRS ARE HARD-TO-DRUG

  • 30-50% of current drug targets are GPCRs but there are only 2 FDA approved antibodies
  • Current antibody drug development methods do not work
  • Random mutagenesis libraries are too inefficient to explore the effective sequence space

SYNTHETIC LIBRARY ADVANTAGE 

  • No immunization required
  • Synthetic mAb libraries focus on effective sequence space
  • Simultaneous screening against multiple targets