DynaPro™ Plate Reader Dynamic and Static Light Scattering Detector
Automated characterization of protein/nanoparticle size, stability and molecular weight in industry-standard microwell plates
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Love the experimental design aspect, super versatile instrument.
LNP characterization
Great set up and seamless user interface.
Review Date: 23 May 2022 | Waters | Wyatt Technology
Great machine and outstanding company.
Get the size of nanocarriers.
Easy to use, reliable, very friendly keto help staff and always available to help. The machine is at heart of what we do.
Review Date: 14 Dec 2021 | Waters | Wyatt Technology
By far the best option for a DLS plate reader.
Protein aggregation
Everything about the instrument is straightforward and intuitive. I am especially impressed with the software; setting up experiments, interpreting and processing data, couldn't be easier.
Review Date: 7 Jul 2021 | Waters | Wyatt Technology
Highly recommend this plate reader! Well worth the money.
Characterizing solution properties of macromolecules
Excellent services whenever needed! I highly recommend them.
Review Date: 7 Jul 2021 | Waters | Wyatt Technology
Great instrument! Extremely useful and essential for conjugate analysis.
Analyzing protein conjugates
Great instrument to evaluate the conjugate product, highly reliable and reproducible results for successful conjugation, both quantitatively and qualitatively. Enjoy the versatility of applications. Highly recommend for polymer, polysaccharide, protein and nanoparticle applications.
Review Date: 7 Jul 2021 | Waters | Wyatt Technology
Great instrument that is used almost daily in my lab.
Aggregation, AAV
The instrument is very valuable for pre-screening for large aggregates when running VGT samples. Also works well for screening beads for filtration purposes. We use this for many other applications as well.
Review Date: 7 Jul 2021 | Waters | Wyatt Technology
Multitasking high throughput instrument. Has deep data analysis features built in.
Biophysical characterization of viruses, antibodies and nanoparticles
The instrument is very technical and the manual the vendor provided is very useful. I could contact the sales team anytime and they handle issues quickly.
Review Date: 24 Dec 2020 | Waters | Wyatt Technology
These instruments allow us to ensure the high quality of the proteins we use for our research.
Protein oligomeric state and aggregation; protein/protein and protein/DNA interaction etc.
We have been using Wyatt instruments for many years and have been very happy with these instruments and Wyatt's services and tech support. They have been very helpful in providing guidance and support for our applications.
Review Date: 27 May 2020 | Waters | Wyatt Technology
Great instrumentation!
kD analysis of antibody solutions
The instrument is very easy to use. Wyatt is always very helpful and supportive. They are experts in the field and are willing to go the extra mile to ensure their customers are satisfied and trained correctly.
Review Date: 27 May 2020 | Waters | Wyatt Technology
This is among the most frequently used instruments in our lab.
Structural biology and biochemistry
I like several aspect of this equipment like the precision and accuracy of measurements of light scattering using small amounts of sample. Fast and easy for the determination of macromolecular sample quality before using in crystallization or functional assays.
Review Date: 27 May 2020 | Waters | Wyatt Technology
The DynaPro™ Plate Reader performs automated analysis of the size and molar mass of peptides, proteins, polymers, nanoparticles and emulsions using dynamic and static light scattering (DLS and SLS) in microwell plates.
All measurements take place in situ in microwell plates with no additional liquid handling, and samples are fully recoverable. The DynaPro™ enables novel, high-throughput workflows that simply would not be possible with typical cuvette-based DLS instruments.
Features:
- Uses industry-standard, flat-bottom 96, 384 or 1536-well plates
- DLS Sensitivity: 0.125 µg of 14.4 kDa lysozyme
- Hydrodynamic radius (Rh) range: 0.5 – 1000 nm
- SLS sensitivity: 1 mg/mL of 66.7 kDa BSA
- Molar mass range: 1 kDa – 1 MDa
- Minimum sample volume: 4 µL in 1536-well plates
- Temperature control: 4 – 85 °C
- Typical scan time for a fully-loaded 386-well plate: 90-120 minutes
- Infrared laser wavelength of 830 nm, not susceptible to fluorescence
- Embedded camera images the bottom of each well to identify precipitation, turbidity and bubbles
- Touch-panel display for immediate access to data, diagnostics and settings
- Software: DYNAMICS™ analysis software offers easy Experiment Builder method setup; comprehensive analysis of size and size distributions, molar mass, diffusion interaction parameter kD, second virial coefficient A2, thermal behavior Tagg/Tm/Tonset, DLS-based viscosity; versatile heatmap display of results; full export of all results; optional 21CFR11 support for GMP
Applications:
- Screen biotherapeutic candidates and formulations for developability and stability.
- Protein quality control before interaction screening
- Optimize protein buffers for crystallization and purification
- Identify ideal dissolution and processing conditions for nanoparticle or polysaccharide production
- Critical micelle concentration and temperature of surfactants or polymers
