DS-11 Series Spectrophotometer / Fluorometer
DeNovix takes spectrophotometry to a whole new level of performance with the DS-11 Series. This easy-to-use, compact spectrophotometer delivers full spectrum UV-Vis analysis and fluorescence capability, making it ideal for rapid nucleic acid and protein quality control.
DS-11 FX+ Spectrophotometer / Fluorometer
Receive your quote directly from the manufacturer.
The best instrument for easiest quantification and purity checks
Quantification of RNA
We would quantify almost more than 10 samples at a time and it would be so quick and we don't even have to recheck that the results are so accurate. Coming to accessibility, it's so easy to use, we just had to tell our juniors how to use they wouldn't even need us to demonstrate it.
Review Date: 29 Jun 2026 | DeNovix
Reliable, easy, compact
Nucleic acid quantification
The DeNovix DS-11 Series is a compact and highly practical spectrophotometer/fluorometer designed for routine laboratory workflows. It combines UV-Vis absorbance with fluorescence-based quantification, making it a versatile platform for measuring nucleic acids and proteins with minimal sample volume. One of the instrument’s strongest advantages is its ease of use. The interface is intuitive, setup is straightforward, and the workflow is well-suited to busy labs that need fast, reproducible results without extensive training. Overall, the DS-11 Series is a solid choice for laboratories seeking a reliable, space-saving, and efficient quantification instrument. Its combination of usability, sensitivity, and workflow convenience makes it especially appealing for research environments that value consistency and speed.
Review Date: 29 Jun 2026 | DeNovix
Very good results, very happy. Resultados muy buenos, muy contento
Nucleic acid quantification/ Cuantificación de ácidos nucleicos
Excellent handling and processing of nucleic acid samples. Excelente uso y manejo para las muestras de ácidos nucleicos.
Review Date: 29 Jun 2026 | DeNovix
Easy and good technology
Manufacturing and technology
I had a great experience with the DS-11 Series process. Everything was simple, smooth, and easy to understand. The staff were helpful, professional, and guided me clearly through each step. The process was quick, organized, and stress-free. I really appreciate the excellent service and positive support throughout. Highly recommended for anyone applying for the first time!
Review Date: 31 May 2026 | DeNovix
Versatile and user friendly
Human genetics
We love ds-11. The interface is fast and fluid. It has many options and it is very versatile. The wifi upload transfer option is super convenient. You have to be careful not to let the samples dry out on the reader/sensor, but that happens with all devices.
Review Date: 19 May 2026 | DeNovix
Easy to use, accurate, and consistent results!
Quantification
We love that the DeNovix requires very little training for all lab members with different backgrounds. Easy to use, accurate, and consistent results!
Review Date: 30 Apr 2026 | DeNovix
This is a necessary instrument for any lab doing cell culture.
RNA + DNA concentration, purity
This is a necessary instrument for any lab doing cell culture. It measures RNA + DNA concentrations and purity accurately for epigenomics research.
Review Date: 30 Apr 2026 | DeNovix
Nice interface and very easy to use
Quantification of nucleic acids
Our lab demoed a unit for a week. We ran about 300 DNA samples using the spectrophotometer feature. We loved it. The interface was easy to use. The auto run feature made running 300 samples just a little bit easier. We didn’t have to do any reruns because of the column breaking. Was definitely a step up from our 20 year-old Nanodrop that has served us well. We haven’t purchased the instrument but five stars for sales care in general. The team was very helpful and did not hesitate to give us a demo unit for a week. The price point is what you would expect for an instrument like this.
Review Date: 30 Apr 2026 | DeNovix
Of the potential to test / Dal potenziale da testare
FFPE RNA quantification / Quantificazione rna FFPE
Simple and intuitive interface, performance under stress still needs to be tested. Hopefully, it will last over time. / Interfaccia semplice e intuitiva,le prestazioni sotto stress sono ancora da testare. Speriamo duri nel tempo.
Review Date: 30 Apr 2026 | DeNovix
Reliable and precise fluorimeter for DNA quantification / Fluorimetro affidabile e preciso per la quantificazione del DNA
Quantification of nucleic acids / Quantificazione degli acidi nucleici
I use the DeNovix fluorimeter daily in our molecular biology laboratory for DNA quantification, particularly within NGS workflows (16S metagenomics) and library preparation. The instrument has proven to be extremely reliable and precise, especially when working with the dsDNA Broad Range and High Sensitivity kits, allowing us to cover a wide range of concentrations without the need to change platforms. One aspect that I appreciate greatly is the reproducibility of the data; even with complex samples or high concentrations, the results are consistent and stable, which is essential to ensure the quality of the libraries to be sequenced. From an operational standpoint, it is very simple and quick to use, the setup is immediate, the software is intuitive, and it allows smooth workflow even with high numbers of samples. Utilizzo il fluorimetro DeNovix quotidianamente nel nostro laboratorio di biologia molecolare per la quantificazione del DNA, in particolare nell’ambito di workflow NGS (16S metagenomica) e preparazione di librerie. Lo strumento si è dimostrato estremamente affidabile e preciso, soprattutto lavorando con il kit dsDNA Broad Range e High Sensitivity, permettendoci di coprire un ampio range di concentrazioni senza necessità di cambiare piattaforma. Un aspetto che apprezzo molto è la riproducibilità dei dati, anche su campioni complessi o con concentrazioni elevate, i risultati sono coerenti e stabili, cosa fondamentale per garantire la qualità delle librerie da sequenziare. Dal punto di vista operativo è molto semplice e rapido da utilizzare, il setup è immediato, il software è intuitivo e consente di lavorare in modo fluido anche con elevati numeri di campioni.
Review Date: 30 Apr 2026 | DeNovix
DeNovix takes spectrophotometry to a whole new level of performance with the DS-11 Series. This easy-to-use, compact spectrophotometer delivers full spectrum UV-Vis analysis and fluorescence capability, making it ideal for rapid nucleic acid and protein quality control.
World’s Top-Rated 1 µL Spectrophotometer
- Three Modes in One: 1 µL UV-Vis, Fluorescence, and Cuvette
- Eliminate Measurement Errors: SmartPath™ Technology Enables Real-Time Optimization of Every Sample in as Little as 2 seconds
- Widest Dynamic Range:
- Microvolume UV-Vis: 0.75 - 37,500 ng/µL (dsDNA)
- Fluorescence: 0.0005 - 4000 ng/µL (dsDNA)
- Multi-Award Winning: Trusted by Thousands of Researchers Worldwide
- Maintenance-Free Design: No Recalibration Required
- Flexible Export and Connectivity: Wi-Fi, USB, Email, Ethernet, and More
Ready to improve your sample quantification? Experience the DS-11 Series Spectrophotometer / Fluorometer in your lab with our Free Trial program, schedule a call with our applications team to discuss your particular application, or Request a Quote to receive pricing information.
Specifications
| Microvolume range | 0.75 – 37,500 ng/µL (dsDNA) |
| Fluorescence range | 0.0005 – 4,000 ng/µL (dsDNA) |
| Absorbance accuracy | 1.5% at 0.75 AU at 260 nm |
| Wavelength(s) | UV-Vis: 190 to 840 nm, Green LED: 525 nm (490-558 nm excitation), 565-650 nm (emission), Red LED: 635 nm (613-662 nm excitation), 665-740 nm (emission), Blue LED: 470 nm (442-497 nm excitation), 514-567 nm (emission), UV: 375 nm (361-389 nm excitation), 435-485 nm (emission) |
| Sample volume | 0.5 to 1 µl |
| Applications | 1 µL UV-Vis or cuvette absorbance DNA, RNA, ssDNA quantification with purity measurements (260/280 and 260/230 ratios), purified protein (A280) up to 750mg/ml BSA, peptide analysis (A205/215), fluorescent quantification assays (preconfigured or custom) |
| Wavelength accuracy | 0.5 nm (UV-Vis) |
| Dimensions | 20 x 33 cm (WxL) |
| Measurement time | 2 seconds |
| Connectivity | Wi-Fi, ethernet, 3 USB ports |
Brochures
DS-11 Series Brochure
Accurate quantification of DNA, RNA, and protein can be challenging when working with low‑volume samples, contaminants, or inconsistent measurement conditions. Researchers often need reliable, sensitive tools that maintain data quality without frequent maintenance or recalibration.
The DS-Series combines microvolume UV‑Vis, fluorescence, and intelligent QC algorithms to deliver sensitive, confident measurements. Explore how it aims to help scientists streamline workflows, improve sample assessment, and generate trustworthy results across a wide range of applications.
Sample quality control: Absorbance vs fluorescence
Explore this comparative breakdown of UV-Vis absorbance and fluorescence to support better decision-making in sample quality control. Gain insights into the unique advantages of each method and discover the range of DeNovix's instrument models designed to enhance the accuracy and efficiency of your quantitation workflows.
Resource details:
Resource type: Scientific poster
Page count: 1
Read time: 2 mins
SmartPath technology explained
This resource demonstrates the ability of a small volume spectrophotometer to produce both accurate and reliable results with the support of DeNovix SmartPath™ technology. Equipped with precise pathlength control, learn how this technology can help keep pathlength within specification to elevate your microvolume spectrophotometer performance.
Resource details:
Resource type: Application note
Page count: 1
Read time: 2 mins
Absorbance and fluorescence quantification for confident sample QC
Master the science of precise biomolecular analysis with DeNovix’s expert guide to absorbance and fluorescence techniques. This eBook explores the strengths of each method, offering practical insights into purity assessment, assay performance, and optimal workflows for nucleic acid and protein quantification. Learn how the DS-11 Series Spectrophotometer/Fluorometer delivers unmatched sensitivity, specificity, and ease of use, all in one compact system.
Resource details:
Resource type: Application note
Page count: 26
Read time: 39 mins
DS-Series spectrophotometers/fluorometers
Discover how the DS-11 Series spectrophotometers/fluorometers from DeNovix combine 1 µL UV-Vis, cuvette UV-Vis, and fluorescence into one instrument. Explore how the DS-11 Series combines the ease of use, wide dynamic range, and contamination detection of UV-Vis with the enhanced sensitivity and specificity of fluorescence quantification. This flexibility allows the DS-11 Series to excel in a wide range of applications.
Absorbance & fluorescence: Your guide to quantification & quality control
Fluorescence and UV-vis absorbance are complementary techniques for the quantification and quality control (QC) of samples. Each method has advantages depending on the application and sample being quantified.
This eBook provides a comprehensive guide to absorbance and fluorescence techniques for quantitation and quality assessment of samples, when to implement each method, how to troubleshoot abnormal ratios, and much more.
Download to explore content including:
- Purity ratios
- Quality control of dsDNA for NGS
- Performance data of microvolume nucleic acid
- dsDNA assay concentration limits
- RNA assay performance data
Absorbance and fluorescence quantification with the DS-11 Series Spectrophotometer/Fluorometer
Download this application note to find out more about how the DeNovix® DS-11 Series Spectrophotometer/Fluorometer enables precise absorbance and fluorescence quantification across a wide dynamic range. The dual-mode spectrophotometer is equipped with SmartPath® Technology, which facilitates accurate and reproducible measurements for both cuvette and 1 µL absorbance modes.
Sample QC: Absorbance or Fluorescence?
The DS-11 FX Series enables both absorbance and fluorescence measurements in one instrument. The combination of absorbance and fluorescence provides greater confidence and accuracy when measuring samples and is a protocol requirement in applications such as Next Generation Sequencing.
DS-11 Spectrophotometer EasyApps Highlights
Find out about the features that make the DeNovix DS-11 Spectrophotometer a powerful and easy-to-use platform, including common workflow apps, kinetics measurement, and a variety of useful built-in tools.
DS-11 Spectrophotometer Data App Highlights
The DeNovix DS-11 has an integrated data app for the easy export of data. This application note highlights the key features and functionalities of the app.
Accurate and Precise GFP Quantification with DeNovix Fluorometer
Green fluorescent protein (GFP) is widely used in molecular and cell biology as a reporter gene for expression of proteins. GFP is an intrinsically fluorescent protein that is easily detected using a fluorometer or fluorescence microscope. This application note details a method of quantifying the GFP fluorophore using the DeNovix QFX Fluorometer.
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24 March 2026
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DeNovix celebrates Diamond Seal of Quality Award at AACR 2026
Discover how DeNovix is expanding access to rapid, flexible sample quantification for life science labs. In this SelectScience interview, Kevin Kelley, Business Director and Vice President at DeNovix, discusses the DS-11 Series Spectrophotometer / Fluorometer and its recognition with a SelectScience Diamond Seal of Quality Award. Kevin highlights how customer feedback has shaped DeNovix’s growing product portfolio, from affordable and high-throughput quantification solutions to the newly launched Squid Full Range Pipette.
This video was filmed at AACR Annual Meeting 2026.
Instrument overview of the DS-11 Series Spectrophotometer / Fluorometer
This demonstration video showcases the DeNovix DS‑11 Series Microvolume Spectrophotometer and Fluorometer, highlighting its ability to perform fast, accurate UV‑Vis and fluorescence measurements using minimal sample volumes. Designed for everyday laboratory workflows, discover how the DS‑11 Series combines ease of use with reliable performance for routine biomolecular analysis.
DS-11 on-demand demo
A demonstration of the award-winning DS-11 Series spectrophotometer / fluorometer.
DeNovix EasyApps User Accounts
In this video, learn about the DeNovix Accounts app and how you can configure your DeNovix spectrophotometers and fluorometers for a variety of features including password protected accounts, preferred methods, measurement modes and more.
DeNovix Inc. Receives the Reviewers’ Choice Award™ for Life Sciences Product the Year
The 2017 Reviewers’ Choice Award™ for Life Sciences Product the Year was awarded to DeNovix Inc., for its DS-11 FX+ Spectrophotometer / Fluorometer, a product which combines fluorescence and microvolume absorbance methods in a single, compact instrument. Hear Kevin Kelley, Business Director, DeNovix Inc., describe what product reviews mean to them and their customers, in this video filmed following the awards ceremony at AACR 2017.
DNA Analysis of Darwin Collection to Tell Story of Ancient Man’s Migration: Sensitive DNA Quantitation Using the DeNovix Inc. DS-11 FX
Dr Alejandra Perotti, School of Biological Sciences, University of Reading, discusses the techniques and technologies enabling her research into the interactions of arthropods, including their role in evolution, archaeobiology and forensic acarology. Hear how the DeNovix Inc. DS-11 FX Spectrophotometer / Fluorometer provides the sensitivity required to quantitate DNA extracted from a single mite or even mite egg. Learn how Dr Perotti will use this technology to investigate a historical collection of lice, collected by Charles Darwin, Alfred Wallace and other expert entomologists, to understand early human migration.
Diamond status is awarded to DeNovix with a new Seal of Quality Award
This is only the third time a Diamond Seal of Quality has been awarded to a product
Top-rated lab technology by women in science
SelectScience celebrates innovation and excellence this International Women’s Day
Accelerating science with technology: The hero lab products you can’t live without
To recognize 25 years of accelerating science, we’re highlighting reviews on innovative technologies and your laboratory essentials
10 lab products making their mark in protein biology research
From sample prep to downstream analysis, discover the products making a difference for other scientists in your field
10 top-rated lab products win Seals of Quality at Virtual Summit on Cancer and Immunology Research
The Incucyte Live-Cell Analysis System from Sartorius becomes the fifth product in history to be awarded a Platinum Seal of Quality
DeNovix launches new RNA quantification assay
DeNovix Inc. expands its fluorescence quantification range with the introduction of the new DeNovix RNA Assay.
DeNovix becomes sponsor at Tufts Launchpad BioLabs
DeNovix has provided a CellDrop™ FL Automated Cell Counter and a DS-11 FX+ Spectrophotometer / Fluorometer for use by the facility’s resident companies
Science Industry Celebrates Successful First Year of ‘Invaluable’ Seals of Quality
Waters, BioTek Instruments, PerkinElmer, Hamilton among the latest companies recognized for top-rated lab products that scientists worldwide love to use
