CrownBio Preclinical Formulation Services by Crown Bioscience

Manufacturer Crown Bioscience
DEVELOP THE BEST FORMULATION STRATEGY FOR YOUR DRUG TO ENSURE OPTIMUM PERFORMANCE.   CrownBio provides a full range of services from pre-formulation development, pre-clinical formulation development and supporting analytical development services. Pre-formulation studies in combination with analytical methods are critical to identifying the best formulation strategy for a particular compound. Certain candidates present specific challenges such as low bioavailability, poor solubility an... Read more


CrownBio Preclinical Formulation Services by Crown Bioscience product image
CrownBio Preclinical Formulation Services

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DEVELOP THE BEST FORMULATION STRATEGY FOR YOUR DRUG TO ENSURE OPTIMUM PERFORMANCE.

 

CrownBio provides a full range of services from pre-formulation development, pre-clinical formulation development and supporting analytical development services. Pre-formulation studies in combination with analytical methods are critical to identifying the best formulation strategy for a particular compound. Certain candidates present specific challenges such as low bioavailability, poor solubility and/or permeability and poor physical stability. Formulation development can be helpful in overcoming many of these issues.

PRE-FORMULATION SERVICES:

  • Solubility and pH-rate Profile
  • Log D/Log P
  • Stability Evaluation (solution and solid)
  • Polymorph Screening
  • Salt form selection
  • Purity Determination
  • Hygroscopicity Studies
  • Physicochemical characterization
  • Particle Size Distribution
  • Excipient Compatibility

FORMULATION SUPPORT:

  • Early formulations for PK, PD and toxicological evaluation
  • Novel formulations: nano-suspension, SEDDS and solid dispersions
  • Microscale drug characterization and evaluation
  • Drug developability assessment