Corning® Supersomes™ P450 Inhibition Kit CYP3A4/DBF, 1/Case by Corning Life Sciences

Kit Components:• CYP3A4 + P450 Reductase + Cytochrome b5• Control: Insect Cell Membrane Protein• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)• DBF (Dibenzylfluorescein): Fluorescence substrate, 0.15 mg• KTZ (Ketoconazole): CYP3A4 selective positive control inhibitor, 0.008 mg• Fluorescein: Metabolite standard (10 µM ... Read more


Corning® Supersomes™ P450 Inhibition Kit CYP3A4/DBF, 1/Case by Corning Life Sciences product image
Corning® Supersomes™ P450 Inhibition Kit CYP3A4/DBF, 1/Case


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Kit Components:
• CYP3A4 + P450 Reductase + Cytochrome b5
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• DBF (Dibenzylfluorescein): Fluorescence substrate, 0.15 mg
• KTZ (Ketoconazole): CYP3A4 selective positive control inhibitor, 0.008 mg
• Fluorescein: Metabolite standard (10 µM in distilled water)

Note:
• Freeze/thaw stability: This CYP3A4 inhibitor screening kit was subjected to 10 freeze thaw cycles without a change in IC50 value for ketoconazole or a significant loss of signal to noise
• xx = Actual values can be found on the data sheet accompanying each shipped product

Preparation and Storage
Store at -80°C

Product Overview

Corning® Supersomes™ P450 Inhibition Kit CYP3A4/DBF, 1/Case by Corning Life Sciences product image

Corning® Supersomes™ P450 Inhibition Kit CYP3A4/DBF, 1/Case

Manufacturer Corning Life Sciences

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