1290 Infinity II LC System by Agilent Technologies

4.2
/
5.0
  |  15 reviews
Experience unmatched performance for ultimate confidence in your results. The new Agilent 1290 Infinity II LC system embodies the future of UHPLC — with the exceptional reliability and robustness you expect from Agilent, plus breakthrough technologies to maximize the efficiency of your business in three dimensions. Maximize Analytical Efficiency More chromatographic resolution – specially designed components in the sample flow path achieve lowest system dispersion. Higher peak capa... Read more


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1290 Infinity II LC System
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Average Rating: 4.2
15 Scientists have reviewed this product

5 out of 5
Ease of use
4 out of 5
After sales service
4 out of 5
Value for money


  • Status:

    Advanced Reviewer
  • Member since: 2019

  • Organization: SIA PharmIdea



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Agilent HPLC is part of my family!
Rating: 4.7

  • Application Area: Pharma industry

"Good equipment for effective analysis! Useful in method validation and for routine work life."

Review date: 11 Jun 2019 | 1290 Infinity II LC System
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Suburban Testing Labs



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
Very easy to use.
Rating: 4.7

  • Application Area:Sample analysis

"Very easy to use."

Review date: 27 Mar 2019 | 1290 Infinity II LC System
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Suburban Testing Labs



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Easy to use.
Rating: 4.7

  • Application Area:Sample analysis

"Easy to use."

Review date: 27 Mar 2019 | 1290 Infinity II LC System
  • Status:

    Advanced Reviewer

  • Member since: 2018

  • Organization: IDF Inc.



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Excellent for food and food safety analysis.
Rating: 4.3

  • Application Area:Food analysis/food safety

"The 1290 LC with 6460 MS/MS produces excellent chromatography with MS/MS detection at low sensitivity and reproducible results. Easy to take care of an clean the MS/MS. Very robust MS/MS."

Review date: 17 Jan 2019 | 1290 Infinity II LC System
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: AbbVie



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
This product is very easy to use.
Rating: 4.3

  • Application Area:R&D and sample anlaysis

"This product is very easy to use. The built-in software can handle the sample analysis results efficiently and effectively."

Review date: 20 Dec 2018 | 1290 Infinity II LC System
  • Status:

    Advanced Reviewer

  • Member since: 2015

  • Organization: CONTINUUS Pharmaceuticals



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Very good for general analytical applications. Good value for money.
Rating: 4.3

  • Application Area:Analysis of different compounds by HPLC

"In my experience, the binary pump in the 1290 is one of the best in the market, it is capable of delivering very high flow rates with very little pulsing, as measured by the baseline noise. The instrument is compatible with several detectors, UV/Vis, DAD, MS, RI, fluorescence etc. [I have mine set up with a DAD and ES-MS in tandem]. The Chemstation software package is very user-friendly and faster to learn than other software systems. And it is much more affordable than its Waters and Thermo counterparts."

Review date: 10 Dec 2018 | 1290 Infinity II LC System
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: National Agriculture research council



  • Ease of use
    5 out of 5
    After sales service
    1 out of 5
    Value for money
    3 out of 5
Good instrument which gives repeatable and reproducible results
Rating: 3.0

  • Application Area:Pesticide residue analysis in food and feed

"Instrument is ideal with user friendly software for trace analysis of multipesticide residue in different environmental matrices. it is easily compatible with DaD and MS/MS. As it has single pump which makes it's results reproducible."

Review date: 03 Dec 2018 | 1290 Infinity II LC System
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: IITB



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Good working with it. Nice operation.
Rating: 4.3

  • Application Area:Protein separation

"Good product. Yes, I would like to recommend it others."

Review date: 26 Jul 2018 | 1290 Infinity II LC System
  • Status:

    Reviewer

  • Member since: 2008

  • Organization: pfizer



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
This is much more rugged than previous UPLC/ UHPLC systems. Plus easier to work on.
Rating: 5.0

  • Application Area:Bioconjugation analytics

"I ordered it with the same tubing that we use for our 1260s. It has had no downside, it can do anything the 1260 can (with more precise gradient control) and hasn't clogged. It has even survived getting pumped dry twice."

Review date: 25 Oct 2017 | 1290 Infinity II LC System
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Virchow Laboratories Ltd



  • Ease of use
    2 out of 5
    After sales service
    2 out of 5
    Value for money
    2 out of 5
Too fancy and less sturdy
Rating: 2.0

  • Application Area:Fine chemicals and Active Pharma Ingredients

"We have been using the instrument for multiple products HPLC analysis. Column connecting ports are too fancy and delicate. Column changing will eat the life of the instrument and encounter with frequent service."

Review date: 04 Nov 2016 | 1290 Infinity II LC System


  • Status:

    Advanced Reviewer

  • Member since: 2008

  • Organization: -



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
Great instrument and flexible configuration option to suit different work flows.
Rating: 4.3

  • Application Area:Analysr drug residues in blood samples

"I am using the Infinity II Series LC as a separation front end for my QTOF instrument in drug screening. The LC provides very robust performance and it is also easy to maintain. Built-in functionality such as the autosampler purging and washing helps reduce carryover which is a major concern for the type of work we do. We have another lab using the Infinity II LC, making use of the large volume injection capability to do small to medium scale purification work. This Infinity II LC series is indeed flexible and versatile, making it suitable for small and medium scale types of work flow."

Review date: 24 Aug 2016 | 1290 Infinity II LC System
  • Status:

    Advanced Reviewer

  • Member since: 2008

  • Organization: -



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Good LC system that I would recommend for any LC-MS and UHPLC users.
Rating: 4.7

  • Application Area:Analyze drugs of abuse in urine samples.

"I use the 1290 Infinity LC as a separation front-end with a MS for the screening and detection of drugs of abuse in urine and plasma samples. Works great as a front end for LC-MS applications. Provides fast UHPLC separations that goes well with fast MRM detection that I am using. The LC is also easy to maintain and robust in performance. It lets me customize the system for both conventional analytical LC flow rates as well as fast LC flow rates. Very flexible. "

Review date: 21 Mar 2016 | 1290 Infinity II LC System
  • Status:

    Reviewer

  • Member since: 2008

  • Organization: Quatest 2



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
Rating: 4.0

  • Application Area:Food, Environment

"This equipment easy to use, we can apply for many fields in my lab with high quality results, high stability, good services after sales"

Review date: 09 Nov 2015 | 1290 Infinity II LC System
  • Status:

    Reviewer

  • Member since: 2014

  • Organization: Morton Grove Pharmaceuticals



  • Ease of use
    5 out of 5
    After sales service
    3 out of 5
    Value for money
    5 out of 5
Rating: 4.3

  • Application Area:Small molecules and large molecules

"Transferred many products like Oral Solution, Suspension, IR Tablets, ER Tablets, DR Tablets and Injectable Impurity methods from HPLC to UPLC or UHPLC to shorter run time. I will be developing the future products methods using UPLC, UHPLC. "

Review date: 06 Nov 2015 | 1290 Infinity II LC System
  • Status:

    Advanced Reviewer

  • Member since: 2014

  • Organization: XEPA-SOUL PATTINSON (M) SDN BHD



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
User-friendly and minimum maintenance required. After sales has been good
Rating: 5.0

  • Application Area:For analysis of raw materials and finished drug products in pharmaceutical product development

"It is a very user-friendly instrument with minimum maintenance required. The after sales support of the seller too has been commendable."

Review date: 11 Sep 2015 | 1290 Infinity II LC System

Experience unmatched performance for ultimate confidence in your results.

The new Agilent 1290 Infinity II LC system embodies the future of UHPLC — with the exceptional reliability and robustness you expect from Agilent, plus breakthrough technologies to maximize the efficiency of your business in three dimensions.

Maximize Analytical Efficiency

  • More chromatographic resolution – specially designed components in the sample flow path achieve lowest system dispersion.
  • Higher peak capacity for challenging separations ­– switch easily between single dimension UHPLC and the ultimate chromatographic power of 2D-LC.
  • Lower carryover for uncompromised data quality – multiwash capabilities of the 1290 Infinity II Multisampler reduce carryover to less than 10 ppm even for challenging compounds such as chlorohexidine.
  • Unique detection capabilities - combine lowest detection limits with an ultra-wide dynamic range by using the new 1290 Infinity II HDR- DAD or 1290 Infinity II ELSD.

Maximize Instrument Efficiency

  • Faster injection cycles (< 5 seconds) with dual needle injection for higher sample throughput.
  • Higher sample capacity per bench space – up to 6144 samples within the footprint of a standard Agilent stack.
  • Significantly better usability - dead-volume-free UHPLC fluidic connections can be easily achieved by the revolutionary A-line quick-connect fittings.
  • Flexibility for all applications – due to the wide power, temperature and automatically scalable injection range, gradient options and intelligent system emulation technology.

Maximize Laboratory Efficiency

  • Seamless transfer of methods between LCs, regardless of the brand – facilitated by Intelligent System Emulation Technology (ISET) delivering unchanged retention time and peak resolution.
  • Seamless integration in your chromatography data system – Agilent LC instrumentation runs smoother than ever before when controlled through third-party chromatography data systems such as Waters Empower or Dionex Chromeleon, thanks to the Agilent’s Instrument Control Framework (ICF).
  • Lower total cost of ownership– select from a variety of tools to achieve lowest cost-per-sample.