DynaPro Plate Reader Dynamic and Static Light Scattering Detector by Wyatt Technology Corp.

"I think it is the best DLS system I have used so far. The option to monitor both DLS and SLS at the same time is a big advantage. In combination with the well-plate based measurement principle it is a great screening tool. We use it for a wide range of applications: DLS temperature ramps, accelerated stability studies and high-throughput screening."

"Very easy setup, time saving, and great automation and HTS capability."

"Decent resolution for sub 10 nm organic nanoparticles. However, sometimes gives different results upon measuring the same sample more than once (without removing the cuvette). However, newer instruments seem to be offering concentration and MALS measurements in similar units."

"The instruments are great tools to characterize monoclonal antibodies. They are always consistent and reliable in producing high quality data."

"Wyatt analyzers are easy to use, the follow up response is excellent."

"DLS from Wyatt is very easy to use. Fast and reliable data about your protein solutions. New and updated software allows for easy setup of temp ramping and temp dependent protein aggregation."

"We just got the DynaPro Plate Reader III and it is a great addition to our lab. Results are of high quality and reproducibility, all with an intuitive and well laid out user interface. The instrument is often used as a pre-cursor to or to consolidate data from SAXS protein analysis. We often work with small concentrations and the plate reader has a high enough sensitivity for our purposes."

"The Instrument is very easy to use and highly recommended if you have many samples. If you are not sure how to use a special feature, Wyatt offers very good and helpful technical notes. The measurement of the A2 is reproducible. If there are too many aggregates in the mAb solution, it is very hard too reproduce the results. The after sales care is excellent! If there is a problem they will help you within 24 h. The value for Money is ok. The Instrument is very expensive but this is compensated by the good results you get."

"The DynaPro Plate Reader II is a great instrument to use in your lab for quick and easy studies on particles in solutions. I use it primarily to help use select buffers to suspend and store our proteins. The end goal for me is protein crystallization and this DLS instrument has been involved with the crystallization of over 4 monoclonal antibodies. I would recommend this instrument to all working on similar projects."

"We use the instrument very frequently to analyze protein aggregates and to also analyze the removal of aggregates. The instrument is very easy to use and the results are very reproducible."

"The first DLS instrument that enables high-throughput sizing and screening of pharmaceutical and nanoparticle formulations and only requires low sample amount."

"Great product. Generally easy to use and the instrument almost never needs maintenance or repair."

"I use the DynaPro Plate Reader III for biophysical characterization and protein formulations. Our lab used to make DLS measurements with a Zetasizer which required a new cuvette and fairly large volume for every sample. Because the DynaPro measures samples in a well plate, the throughput is much higher, and the sample volume requirement is much smaller. In my experience, the data quality from the Wyatt Plate Reader is superior to other DLS manufacturers. Highly recommended!"

"The plate reader has been a very reliable instrument that delivers high throughput data with a quality close to the theoretical limit for the analysis. When used properly the data is very reliable. Wyatt does a good job offering training and technical notes to help scientists learn how to properly collect and use the data. Love the camera to check for bubbles, mis-filling or precipitation events. Within the expected accuracy and resolution of the method, the information on diffusion coefficients and estimates of nano-particle sizes are very valuable."

"The Plate Reader is very user-friendly, and the ability to use low volume microplates (conserving precious sample) is a definite plus."

"Changed the way we think of DLS. Use it to screen large sets of conditions"

"We have purchased several of analytical instruments from Wyatt. The technical service is superb. Wyatt team of engineers have supported us with technical questions for many year. Best customer service for instrumentation."

"This non chromatographic method for size variant analysis is a very useful technique and DLS has provided very valuable data for us. It is easy to use, rapid, high throughput and very sensitive method. Once you know how to interpret the data this could be a very valuable tool to any protein analytical and formulation lab."

"We use our plate reader all the time. It's and excellent way for us to characterize the reagents and compounds we are working with. We have also used this to scout buffer conditions during assay development. We find the DynaPro plate reader to be very helpful in our drug discovery efforts."

"We have been used Wyatt Plate Reader for more than 6 years for formulation developments. Basically it is easy to use and provides good data."

"Good instrument to perform buffer screenings and rankings of leads. Makes it possible to stress a sample in different buffers and analyze it fast. good for selecting the right buffer!"

"This is the first instrument we go to when receiving or generating new samples in our lab- we quickly have an assessment on purity, which lets us plan our subsequent experiments. It is non-intrusive, and the sample can be recovered. Programmed data collection and temperature ramping facilitate rapid acquisition of data under multiple conditions."

"In using the Wyatt Plate Reader for our protein applications, we have seen very reproducible results over large time-spans (multiple years). The plate reader is very easy to use. After reading the user manual, speaking to technical representatives and reviewing the data interpretation guide, I was able to generate data quickly and reproducibly. The plate reader is excellent for high throughput applications in batch mode. The software is very user-friendly and I was able to start using the instrumentation quickly. The Wyatt technical team is excellent in both their knowledge and their response times. I am always able to get help in a timely manner that does not impede project timelines. Because of Wyatt's excellent service, I believe that any Wyatt product (including the Plate Reader) is a good value for the money invested."

"Very effective in protein size and uniformity analysis. High quality and reproducible results. User friendly. When we got this instrument, the application scientist from Wyatt immediately taught us how to use this instrument properly. When I do a measurement, it only takes about 15 mins. Great company and instrument "

"The plate reader is very easy to operate and offers a true high throughput analysis, which allows us to perform hydrodynamic size, size distribution, and agglomeration/dispersion state measurements for over 100 nanomaterials in a big variety of cell culture media and water systems. It generates data of high quality and high reproducibility. The built-in kinetics feature also allows systematic agglomeration kinetics measurements, which is essential in understanding the nanoparticle behavior under different testing conditions."

"The plate reader is easy to use but shows some drawbacks. Reproducibility is too low. We use the equipment in routine measurements but unfortunately often have to double check the results with the Mobius DLS. Temperature range, up to 70°C, is too low to characterize thermal (aggregation) stability. Equipment has shown already several breakdowns. The latest was because of dirty optics although it had hat just before a maintenance. It took quite long for Wyatt support to figure out what the problem was and repair costs were unreasonable high."

"This instrument is extremely easy to use. For our purposes in measuring diffusion coefficients of various mAbs in their formulations, it suits our purposes. Our final goal is to achieve a kD value for each mAb, which is a somewhat qualitative effort rather than quantitative. For this reason, I have been less concerned with some slight variability in the diffusion coefficient results. Sample contamination is very common as well, which can lead to less accurate readings, so sample preparation becomes very important. Support from Wyatt employees, whom I have met through training and conferences, has been very good. Some slight confusion has been raised over which diffusion coefficient values to use in the generated data. This is due to multiple views of the data which each give different values. This has been slightly concerning, but not a show stopper for our purposes thus far."

"The instrument is very easy to use and maintain. It is a routine instrument in the lab to check protein and small molecule aggregates without any loss of samples."

"I had a great experience working with DynoPro plate reader II to determine the particle size of my antibody. The great thing is about this instrument is a low solution volume needed for size determination with great sensitivity. "