XBridge Columns
XBridge Columns include a selection of 10 general-purpose and application-specific sorbents that cover a wide range of particles sizes for analytical and preparative HPLC applications. XBridge Column users can quickly develop robust methods using mobile phases throughout the entire pH range of 1-12. XBridge OBD™ Preparative Column users, benefit from high pH and temperature stability to provide increased mass loading f…
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Standard equipment column for inventory
Bioanalysis
Standard LC column to go to for method development, offering a suitable range of stationary phases, good routine performance and reliable.
Review Date: 19 Dec 2024 | Waters
Very recommended
colorant in cosmetics
It can separate some colourants simultaneously with good resolution.
Review Date: 23 Mar 2023 | Waters
High satisfaction for HPLC analysis.
Pharmaceutical R&D
Using the XBridge column for my analysis that have high pH range make the analysis robust. This is because it's difficult to find the HPLC column that have wide pH range with a affordable price and long lasting usage of the column
Review Date: 14 Feb 2022 | Waters
Highly recommended for analytical scientists.
Excellent column for medium size molecules where separation attract neutral to slight basic pH.
Great product for analytical scientists who works on medium size molecules abs separation need neutral to slight basic media.
Review Date: 15 Nov 2021 | Waters
Reproducible results of different lot of columns of Waters. Great
Small molecules and impurity profiling
Due to the chemistry of the column, we could separate the sensitive and positional isomers in one of our raw materials. Method validation done and found column performance very good.
Review Date: 15 Nov 2021 | Waters
For LC researchers, XBridge is a must column to be in rack.
For retention of middle size molecules and slight basic media
Working on basic phases is always challenge for LC researchers. Especially where analyte is not a small molecule. Water's XBridge columns provide a good option to optimize such methods.
Review Date: 16 Aug 2021 | Waters
Great customer service
HPLC Analysis
Found the very good reliable product
Review Date: 8 Feb 2021 | Waters
XBridge columns are the first to come to my mind for a new project!
Analysis of small molecules and degradation product separation
XBridge columns are the most versatile columns that I have used. They are very reproducible and long lasting. I have used them for degradation product separation for many past years with much success!
Review Date: 10 Nov 2020 | Waters
Best column for complicated degradation product separation!
Analysis of small molecules
Waters XBridge columns are the first to come to my mind when I get a new project. They are very versatile and long lasting. I use them for mainly degradation product separation. I have used XBridge C18 and phenyl columns for many applications with much success!
Review Date: 10 Nov 2020 | Waters
One column for the purification of different type of molecules
Purification of new molecules after synthesis
We synthesize new molecules based on peptides or polyethyleneglycol coupled with anticancer drug. It is really difficult to develop analytical methods to purify these molecules, it is why we bought a generic column XBridge. After few months of development, we obtained correct results adjusting gradient conditions according to the molecule studied and results are repeatable.
Review Date: 12 Oct 2018 | Waters
XBridge Columns include a selection of 10 general-purpose and application-specific sorbents that cover a wide range of particles sizes for analytical and preparative HPLC applications.
XBridge Column users can quickly develop robust methods using mobile phases throughout the entire pH range of 1-12. XBridge OBD™ Preparative Column users, benefit from high pH and temperature stability to provide increased mass loading for basic compounds.
- Robust HPLC methods
- Seamless HPLC to UPLC® method transfer
- Preparative scaling for product isolation
- High pH stability
- Long lifetime and high reliability
- Maximum method development flexibility
- High chemical resistance
Ethylene-Bridged [BEH Technology] Hybrids and Their Use in Liquid Chromatography
First Introduced in 1999 in XTerra® columns, Waters patented organic/inorganic Hybrid Particle Technology (HPT) surmounted significant limitations of silica-based reversed-phase packing materials, particularly their hydrolytic instability at high pH. in 2005, second-generation HPT, branded as BEH Technology™, embodied in new ACQUITY UPLC™ BEH Columns and in Waters XBridge™ HPLC columns, marks a new milestone in chromatography.
Scaling of a USP Assay for Quetiapine Fumarate Across Different LC Systems
In this study, the Waters Columns Calculator will be used to scale the USP monograph assay method for quetiapine fumarate an anti-psychotic drug, to smaller particle sized columns.
Utilizing the method scaling guidelines within the USP General Chapter <621>, traditional isocratic HPLC methods are capable of being scaled to columns with smaller particle sizes and shorter lengths. Scaling a USP method enables the use of modern chemistries and LC hardware to deliver improved throughput with decreased solvent consumption all while providing accurate and reproducible chromatographic data. The scaled modifications for the USP quetiapine fumarate assay method enabled the original method run time to be reduced by 57% for a 3 μm column on an ACQUITY Arc UHPLC System and 87% reduction for the 1.7 μm column on an ACQUITY UPLC H-Class PLUS System. The scaled methods maintained the same or improved chromatographic performance in terms of resolution, peak tailing, and retention time and peak area RSD.
Typical Conditions for Analyzing and Isolating the Compounds in the Preparative Chromatography Mixture Standard with an ACQUITY QDa Detector
This application note provides chromatographic method conditions for preparative systems configured with an ACQUITY® QDa® Detector using the Preparative Chromatography Mix Standard as a system test prior to injecting samples for isolation.
Determination of Food Sugars in Fruit Juice Using Evaporative Light Scattering Detection and BEH Amide Column Chemistry
This technical brief describes the analysis and quantification of five food sugars using the robust XBridge™ BEH Amide XP Column chemistry with proven Alliance® HPLC System technology.
Using Isocratic Preparative Liquid Chromatography as a Quick First-Step Purification for Natural Product Isolation
This application note describes a workflow to systematically develop isocratic prep LC methods for target compound isolation from natural product mixtures. Eriocitrin, a polar compound found in peppermint extract, is used as a model to demonstrate the isolation and purification workflow.
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