ResourceSeparations

Ethylene-Bridged [BEH Technology] Hybrids and Their Use in Liquid Chromatography

16 Jan 2019

First Introduced in 1999 in XTerra® columns, Waters patented organic/inorganic Hybrid Particle Technology (HPT) surmounted significant limitations of silica-based reversed-phase packing materials, particularly their hydrolytic instability at high pH. in 2005, second-generation HPT, branded as BEH Technology™, embodied in new ACQUITY UPLC™ BEH Columns and in Waters XBridge™ HPLC columns, marks a new milestone in chromatography.

ACQUITY UPLC BEH Columns

Waters

In 2004, Waters revolutionized liquid chromatography with the introduction of the ACQUITY UPLC System. At the heart of the system was Waters second generation hybrid, the Ethylene Bridged Hybrid (BEH) particle. In 2005, BEH Technology preparative particle sizes (2.5, 3.5, 5 and 10 μm) with the introduction of XBridge between HPLC and UPLC Technology platforms. BEH Technology particles offer: Excellent peak shape and efficiency for basic analytes A rational array of chromatographic selectivity Improvements in chemical stability at mobile phase extremes, particularly at elevated pH

(41)

XBridge Columns

Waters

XBridge Columns include a selection of 10 general-purpose and application-specific sorbents that cover a wide range of particles sizes for analytical and preparative HPLC applications.   XBridge Column users can quickly develop robust methods using mobile phases throughout the entire pH range of 1-12. XBridge OBD™ Preparative Column users, benefit from high pH and temperature stability to provide increased mass loading for basic compounds.   Robust HPLC methods Seamless HPLC to UPLC® method transfer Preparative scaling for product isolation High pH stability Long lifetime and high reliability Maximum method development flexibility High chemical resistance

(72)

Links

Tags