Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer

In this application note, Thermo Fisher Scientific outlines the analytical performance of static headspace (SHS) and solid-phase microextraction using Arrow technology (SPME Arrow) for the determination of benzene, toluene, ethylbenzene, and xylenes (BTEX) and chlorinated and brominated volatile organic compounds (VOCs) in drinking water using a Thermo Scientific™ TSQ™ 9000 triple quadrupole GC-MS/MS system. SHS sampling provided adequate sensitivity to meet the regulatory limits set at 0.3 μg/L for the investigated VOCs and BTEX, with the exception of vinyl chloride. For this compound, the SPME Arrow technique was used to reach the regulatory limits set at 0.1 μg/L.

In this application note, Thermo Fisher Scientific compares the performance of a triple quadrupole mass spectrometer coupled to a gas chromatograph (GC) using hydrogen versus helium as the carrier gas for analyzing polychlorinated biphenyls (PCBs). PCBs are industrial chemicals banned since 1977 due to environmental concerns. The study aims to meet acceptance criteria outlined in US EPA Method 1668. The note discusses the structure and toxicity of PCBs, regulations surrounding them, and the application of GC-MS/MS for analysis.

This application note from Thermo Fisher Scientific details a FIA-MS/MS method using the Thermo Scientific™ Vanquish™ MD HPLC and Thermo Scientific™ TSQ Quantis™ MD MS. The method, validated with ClinSpot™ LC-MS/MS Complete Kits, enables the detection of 12 amino acids and 13 acylcarnitines from dried blood spot samples. It fulfills the requirement for semi-quantitative determination of these compounds, crucial for newborn screening.

Food safety is of paramount importance to public health, and animal products destined for human consumption are closely monitored by global food agencies to ensure that Maximum Residue Limits (MRLs) are not exceeded.

In this veterinary drug residue testing eBook, we consider the Thermo Fisher Scientific suite of LC-MS/MS technologies and their add-ons through a range of case studies demonstrating their use in meat and milk veterinary drug residue testing. We will explore how these analytical methods can tackle specific groups of compounds or high-throughput simultaneous screening of multiple residues, overcoming muscle matrix problems and improving Limits of Quantification (LOQs).

In this application note, Thermo Fisher Scientific demonstrates robust and sensitive quantitation of 10 nitrosamines with a Thermo Scientific™ TSQ Quantis™ mass spectrometer and uses the LC-SRM-MS method to quantify nitrosamine impurities in metformin drug products.

Mass spectrometry is a popular choice of technology in clinical research for the quantitation of immunosuppressant drugs in whole blood samples. A sensitive and robust instrument is required for reliable quantitation workflows. In this study, the robustness of the TSQ Quantis triple quadrupole mass spectrometer for analysis of immunosuppressant drugs in whole blood samples in demonstrated.

In this application note, an analytical method for clinical research for the quantification of 23 antidepressants in human plasma or serum is reported. The analysis includes:

atomoxetine, bupropion, citalopram, desmethylfluoxetine, desmethylmirtazapine, desmethylsertraline, dosulepin, duloxetine, threo-dihydrobupropion, fluoxetine, fluvoxamine, mianserin, milnacipran, mirtazapine, moclobemid, hydroxybupropion, opipramol, paroxetine, reboxetine, sertraline, tranylcypromine, trazodone, and venlafaxine.

In this application note, a clinical research analytical method for the quantification of 35 benzodiazepines in human plasma or serum is reported. The panel includes :

3-hydroxybromazepam, 7-aminoclonazepam, 7-aminoflunitrazepam, 7-aminonitrazepam, α-OH-alprazolam, α-OH-midazolam, α-OH-triazolam, alprazolam, bromazepam, chlordiazepoxide, clobazam, clonazepam, demoxepam, desalkylflurazepam, desmethylflunitrazepam, diazepam, estazolam, flunitrazepam, flurazepam, lorazepam, lormetazepam, medazepam, midazolam, nitrazepam, norclobazam, nordiazepam, oxazepam, prazepam, temazepam, tetrazepam, trazodone, triazolam, zaleplon, zolpidem, and zopiclone.

In this white paper, Suparna Mundodi, Marketing Manager, Clinical Research at Thermo Fisher Scientific, interviews experts Marilyn Huestis, recently retired from the National Institute on Drug Abuse, Michael Vogeser, specialist in Laboratory Medicine and senior physician at the Hospital of the University of the Ludwig-Maximilians-University Munich, Germany, and Lawrence Andrade, Director of Research and Development, Dominion Diagnostics. Their discussion focuses on current trends and challenges in clinical research.

Explore cutting-edge approaches for advancing semi-volatile organic compounds (SVOCs) analysis in water samples

Thermo Scientific software suite improvements deliver enhanced performance, usability, and integration across a wide range of workflows

Collect our three guides for robust and reliable technologies to enable scientists in forensic and clinical laboratories

Collaboration with the Food Safety and Standards Authority of India to develop next-generation chromatography and mass spectrometry workflow solutions