Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer
Test new limits of detection, characterization and quantitation with the latest Tribrid™ mass spectrometer. The Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer is designed to expand performance in advanced proteomics, biopharma and metabolomics applications, including quantitation using isobaric tags, low level PTM analysis, data independent acquisition (DIA), and top down proteomics. The new instrumen…
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
Excellent service from ThermoFisher Scientific
Food chemistry
The service team from Thermo Fisher Scientific is always great. They are committed to making consumers satisfied with their purchase. They provide support on various aspects related to the instrument performance and make sure they tune the instrument to its optimal conditions all the time. Always excellent service from the mass spectrometer engineering team; they are prompt, knowledgeable, and thorough. They quickly diagnosed and resolved the issue, ensuring minimal downtime. Highly recommended for their expertise and professionalism.
Review Date: 22 Jul 2025 | Thermo Fisher Scientific
Great instrument, the software needs an upgrate to be more intutive and user friendly
Proteomics
We receive high quality results with the instrument but the software is a bit confusing to use. I wish the instrument worked with Chromeleon. Xcaliber has too many different nodes to wade through. I also wish the calibration would last longer so we didn't have to calibrate every week.
Review Date: 12 Dec 2022 | Thermo Fisher Scientific
Simple and Efficient
Proteomics
The product works well for our mass spec based protein footprinting. Customer service is top tier and the ease of use is appreciated.
Review Date: 15 Mar 2022 | Thermo Fisher Scientific
Very sensitive to detect low abundant proteins/peptides.
Proteomics
This is high res and high sensitive instrument. I have used it for deep proteome profiling, low abundant antigen peptide identification, low abundant protein identification in high-background matrix such as CSF, MS3 quantification.
Review Date: 28 Oct 2021 | Thermo Fisher Scientific
Best mass spec.
Complex protein characterization
This is the best mass spec on the market.
Review Date: 26 Jul 2021 | Thermo Fisher Scientific
Great result, best instrument for proteomics and metabolomics studies.
Proteomics and metabolomics
Orbitrap Fusion is the best instrument for proteomics and metabolomics studies, it gives me high quality and reproducible results. It is user friendly, easy to handle, data acquisition software is very easy to use. Rating for ease of use is worth five stars, after sales care within servicing period is good but after service period over it is a little bit careless about servicing the instrument, Value for money is very costly so most of research centers unable to buy this instrument.
Review Date: 24 Jul 2021 | Thermo Fisher Scientific
Great results, can’t live without this instrument!
Proteomics
Incomparable resolution for analysis of very complex samples.
Review Date: 15 Jul 2021 | Thermo Fisher Scientific
Qualitative exploration, rapid profiling, and high-resolution quantitation workflows.
Biological research, proteomics, metabolomics and biopharma
This new platform incorporates a brighter ion source, segmented quadrupole, improved ion transmission, and improved ETD performance. Fusion Lumos technology excels at the most challenging applications, including low-level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, as well as MSn analysis of small molecules.
Review Date: 7 Apr 2021 | Thermo Fisher Scientific
Excellent.
Research
Best for your cost.
Review Date: 21 Mar 2021 | Thermo Fisher Scientific
Great results and easy measurements.
Analyze organic and inorganic samples
The service is very effective and powerful. The product is very easy to apply in various fields.
Review Date: 20 Mar 2021 | Thermo Fisher Scientific
Test new limits of detection, characterization and quantitation with the latest Tribrid™ mass spectrometer.
The Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer is designed to expand performance in advanced proteomics, biopharma and metabolomics applications, including quantitation using isobaric tags, low level PTM analysis, data independent acquisition (DIA), and top down proteomics. The new instrument features enhanced sensitivity resulting in improved analyte detection, characterization and quantitation, enabling scientists to perform more comprehensive sample analyses faster and with better accuracy than ever before.
Novel Orbitrap Fusion Lumos MS Features:
- Novel high-sensitivity API interface combines a High Capacity Transfer Tube and an Electrodynamic Ion Funnel for increased ion flux and lower limits of detection
- Advanced Active Beam Guide prevents neutrals and high velocity clusters from entering the resolving quadrupole
- Advanced Quadrupole Technology combines high selectivity and efficiency of transfer for selected ions symmetrically across the isolation window
- Advanced Vacuum Technology improves transmission of high molecular weight ions to the Orbitrap analyzer
- Novel ETD HD—high dynamic range ETD provides significantly increased fragment ion coverage
Established Tribrid MS Features:
- Tribrid architecture — includes quadrupole mass filter, linear ion trap and Orbitrap mass analyzers
- Ultrahigh resolving power up to 500,000 FWHM, with isotopic fidelity up to 240,000 FWHM at m/z 200
- Acquisition rates of up to 20 Hz for both Orbitrap and linear ion trap MSn analyses
- Full parallelization of MS and MSn analyses with intelligent ADAPT™ (All Dynamically Available Parallelizable Time) technology
- Synchronous Precursor Selection (SPS) for MS and MSn experiments significantly increases the number of peptides and proteins identified and improves quantitative accuracy when using isobaric mass tags
- Flexibility of fragmentation — CID, HCD and optional ETD and EThcD available at any stage of MSn with detection in either the Orbitrap or linear ion trap detector enables detailed structure determination of metabolites, glycans and other small molecules
- Universal Method provides maximal peptide identifications without method optimization for samples of unknown concentration, reducing sample and instrument time requirements for routine peptide identifi cation experiments
- Intuitive and flexible drag-and-drop user interface simplifies method development and enables unique and complex workflows
Brochures
Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer - Breakthrough Gains for Quantitative Biology Sensitivity Transformed
The Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ mass spectrometer is the industry-leading high-performance mass spectrometer with enhanced sensitivity facilitated by a new High Capacity Transfer Tube, Electrodynamic Ion Funnel, Advanced Quadrupole Technology, Advanced Vacuum Technology, and ETD HD.
Enhanced Lipid Characterization Using LipidSearch Software
For advanced untargeted lipidomics, Thermo Scientific™ LipidSearch™ software combines information obtained in HCD and CID MS2 and MS3 product ion spectra. This poster demonstrates the use of LipidSearch on a new Tribrid™ Orbitrap™ mass spectrometer for improved detection and characterization of metabolites and lipids.
Top-down Characterization of Monoclonal Antibody on an Orbitrap Fusion Lumos™ Tribrid Mass Spectrometer
This application note describes a method for mass-analysis and top-down characterisation of a monoclonal antibody, conducted on a modified Orbitrap Lumos mass spectrophotometer. LC-MS analysis was performed on the intact monoclonal antibody, the IdeS sub-units and the reduced heavy chain product. ETD HD, UVPD and CID top-down fragmentation modes were applied to obtain the optimal sequence coverage.
Development of an All-Recombinant Intact Protein Standard for LC & MS Application Development & System Suitability Testing
This application note describes the development of a multi-purpose intact protein standard for LC, LC-MS, and LC-MS/MS quality control and application development. Quality and stability of the selected proteins were verified by SDS-PAGE, UV HPLC, infusion-MS and LC-MS, and MS/MS and top-down data was analysed with Thermo Fisher Scientific software packages. The method is applicable to proteins with a wide MW range, m/z range and is compatible for clinical research applications.
Ultra-Fast Analysis of Allergens using Capillary Electrophoresis Coupled to Mass Spectrometry and UVPD
The main goal of this work was to develop a simple and fast strategy allowing simultaneously the identification of allergens and the authentication of fish species. The identification of proteins in food matrices that cause sensitization in individuals or allergic reactions in those individuals already sensitized, represent a major concern for the food industry. Here we explore the application of CE/MS/MS as an accurate and sensitive way to rapidly test for protein allergens in food.
Pushing the Limits of Bottom-Up Proteomics with State-Of-The-Art Capillary UHPLC and Orbitrap Mass Spectrometry for Reproducible Quantitation of Proteomes
In this application note, the cooperative use of an EASY-nLC 1200 system with an Orbitrap Fusion Lumos mass spectrometer to separate a HeLa cell lysate is outlined. Since its inception, bottom-up proteomics has aimed to identify and quantify the complete proteome from a cell, tissue or whole organism. Although many advances have been made in the last 15 years, there are still challenges to overcome.
Optimizing Top Down Analysis of Proteins on Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer
This application note demonstrates the optimization of top down analysis of intact proteins with the goal of maximizing sequence coverage on a Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer.
Low Attomole Limit of Quantification on an Orbitrap Fusion Lumos Tribrid Mass Spectrometer
This application note describes the improved limit of quantification (LOQ) possible for the new Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer by utilizing several targeted and data independent (DIA) methods for peptide quantitation.
Thermo Fisher Scientific Wins Best New Drug Discovery Product of 2015
The Scientists’ Choice Award® for Best New Drug Discovery Product of 2015 was presented to Thermo Fisher Scientific for its Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer. Kerry Parker, SelectScience® Editor-in-Chief, announced the winner and presented the award during the SLAS2016 conference in San Diego, USA.
Top 10 technology launches at ASMS 2022
Catch up on some of the most exciting advancements in mass spectrometry presented at ASMS 2022
Thermo Fisher Scientific collaborates with TransMIT GmbH on a high-performance orbitrap mass spectrometry imaging platform
Co-marketing agreement between Thermo Fisher Scientific and TransMIT allows for high spatial and high mass resolution MSI platform to study complex biological tissues
Next-generation analytical software strengthens data exploration
Thermo Scientific software suite expands capabilities in sample analysis with enhanced flexibility, reliability and customization
Versatile high-resolution mass spectrometer expands Thermo Scientific Orbitrap platform
Thermo Scientific Orbitrap Exploris 240 mass spectrometer drives discovery and identification with quantitative precision and accuracy to meet customers' specific analytical requirements
Thermo Fisher Scientific Announces Collaboration to Advance Disease Biomarker Validation
Thermo Fisher and Newomics to optimize performance of high-throughput analytical workflows
Thermo Fisher Scientific Renews Collaboration to Advance Plasma Quantitation Methods in Proteomics
Thermo Fisher and Biognosys to develop industry-leading mass spectrometry-based workflows for the efficient analysis of proteins in complex biological matrices
Collaboration to Revolutionize Profiling of Large Plasma Sample Cohorts
Thermo Fisher Scientific announces collaboration to improve workflows in protein-based clinical research studies with Evosep at ASMS 2019
New Mass Spectrometer Maximizes Research Insights and Productivity Through Intelligent Data Acquisition Strategies
Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer reinvigorates high-end protein research with expanded analysis capabilities
