NimbleGen SeqCap EZ Library Kits
SeqCap EZ Library is a solution-based capture method that enables enrichment of the whole exome or customer regions of interest in a single test tube. Built upon an optimized design algorithm, SeqCap EZ Library sets a new standard for a simple single-step enrichment method.
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SeqCap EZ Library is a solution-based capture method that enables enrichment of the whole exome or customer regions of interest in a single test tube. Built upon an optimized design algorithm, SeqCap EZ Library sets a new standard for a simple single-step enrichment method.
SeqCap EZ Exome Libraries enable enrichment of the whole exome. Based on the latest database builds and offering a 64Mb sequence capture, SeqCap EZ Exome Library v3.0 enables the discovery of more coding variants. SeqCap EZ Exome Library v2.0 sets a new standard for exome sequencing by giving you the power to capture and sequence the exome on a single lane. SeqCap EZ Exome +UTR Library offers a 96 Mb design to capture the exome and untranslated regions (UTRs). SeqCap EZ Exome Plus provides you with a 64 Mb exome capture with the ability to add up to 50 Mb of your custom targets.
SeqCap EZ Choice Libraries enable enrichment of customer regions of interest and are offered in two configurations: SeqCap EZ Choice Library can capture up to 7Mb custom regions with a single design; SeqCap EZ Choice XL Library can capture up to 50Mb custom regions with a single design. Both libraries are available in 6 different reaction sizes.
SeqCap EZ Developer Libraries enable enrichment of customer regions of interest in non-human genomes. SeqCap EZ Developer Library can capture up to 50Mb custom regions with a single design and is available and is available in 6 different reaction sizes.
Co-optimization of Probes and Polymerases to Drive the Evolution of Targeted Sequencing
This poster demonstrates the capabilities of targeted sequence enrichment using the KAPA HTP Library Preparation Kit and KAPA HiFi HotStart DNA Polymerase. Inefficiencies in library construction and automation-unfriendly workflows have previously meant low throughput and poor performance. By combining enzymes specifically tailored for high performance NGS applications with innovative oligonucleotide probe design, improved library construction and targeted enrichment can be achieved.
Multiplex Sequence Capture for Targeted Resequencing of Candidate Gene Panels in Cancer
Complex, progressive, multigenic, somatic mutation of the genome is now widely accepted as the primary driving force in the evolution of tumor initiation, growth, metastasis and pharmacoresistance for many types of cancer. Different types of tumors, at different stages of progression, are associated with mutations in distinct sets of genes, and there is a pressing need for a sequencing-based method of analyzing panels of candidate genes that can differ for each tumor type. This application note demonstrates the application of multiplex Sequence Capture techniques using custom gene panels for the analysis of somatic genome variation in colorectal tumors.
