Nano DSC
The Nano DSC utilizes capillary cells to achieve highest sensitivity and maximum sample flexibility.
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The Nano DSC differential scanning calorimeter is designed to characterize the molecular stability of dilute in-solution biomolecules. The Nano DSC obtains data using less sample than competitive designs. Solid-state thermoelectric elements are used to precisely control temperature and a built-in precision linear actuator maintains constant or controlled variable pressure in the cell. Automated, unattended continuous operation with increased sample throughput is achieved with the optional Nano DSC Autosampler.
Characterization of biopharmaceutical stability
This application note demonstrates how differential scanning calorimetry can be used to evaluate the stability of antibody‑based biopharmaceuticals, including antibody drug conjugates, using a Nano DSC system. By analyzing thermal parameters such as transition temperature, enthalpy, and onset of unfolding, the method provides detailed insight into how drug loading and linker chemistry affect antibody structure and stability. Discover how this approach enables both qualitative and quantitative assessment of biotherapeutic integrity, supporting formulation development, quality control, and optimization of drug‑to‑antibody ratios.
Novel thermodynamic assay for biomolecular structure stability
This application note demonstrates a thermodynamic approach to assessing biomolecular structure stability using nano differential scanning calorimetry. The method shows how subtle changes in formulation conditions, such as pH and excipient concentration, can significantly influence protein stability, with high sensitivity and reproducibility. Using the Nano DSC system, the study highlights how thermodynamic profiling enables precise detection of structural changes without the need for sample labeling or modification, supporting more informed decisions in drug development, formulation optimization, and storage stability monitoring.
Thermal stability analysis of antibodies using differential scanning calorimetry
This application note explores the use of differential scanning calorimetry (DSC) to assess the thermal stability and structure‑function relationships of antibodies. Using the Nano DSC system, the study demonstrates how unfolding transitions, thermodynamic parameters, and domain‑level interactions can be characterized with high sensitivity. The method provides insight into antibody conformational stability by analyzing thermal denaturation profiles and deconvoluting complex thermograms, supporting applications in biopharmaceutical development, formulation optimization, and quality assessment.
