Characterization of biopharmaceutical stability

This application note demonstrates how differential scanning calorimetry can be used to evaluate the stability of antibody‑based biopharmaceuticals, including antibody drug conjugates, using a Nano DSC system. By analyzing thermal parameters such as transition temperature, enthalpy, and onset of unfolding, the method provides detailed insight into how drug loading and linker chemistry affect antibody structure and stability. Discover how this approach enables both qualitative and quantitative assessment of biotherapeutic integrity, supporting formulation development, quality control, and optimization of drug‑to‑antibody ratios.