ResourceDrug Discovery & Development
Characterization of biopharmaceutical stability
12 May 2026This application note demonstrates how differential scanning calorimetry can be used to evaluate the stability of antibody‑based biopharmaceuticals, including antibody drug conjugates, using a Nano DSC system. By analyzing thermal parameters such as transition temperature, enthalpy, and onset of unfolding, the method provides detailed insight into how drug loading and linker chemistry affect antibody structure and stability. Discover how this approach enables both qualitative and quantitative assessment of biotherapeutic integrity, supporting formulation development, quality control, and optimization of drug‑to‑antibody ratios.
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Nano DSC
TA Instruments - Waters LLCThe Nano DSC utilizes capillary cells to achieve highest sensitivity and maximum sample flexibility.
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Thermal Analysis EquipmentThermal analysis equipment is used for measuring heat flow, weight loss, dimension changes or thermomechanical properties and is important for analyzing a material’s performance and stability. Thermal analysis equipment includes differential scanning calorimeters (DSC), thermogravimetric analyzers (TGA), thermomechanical analyzers (TMA), dilatometers, thermometers, vapor sorption analyzers, boiling and melting point apparatus. Thermal analyzers can reveal properties such as melting, crystallization and glass transitions or other processes such as oxidation, decomposition, volatilization, as well as coefficients of thermal expansion and modulus. Find the best thermal analysis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Antibody Drug ConjugatesProtein StabilityDrug FormulationDifferential Scanning Calorimetry