DelsaMax Series - Particle Analyzers

Ultra-small nanoparticles, such as quantum dots and fullerene molecules, are difficult to measure accurately in solution. In this application note, we demonstrate a way to exploit the dynamic light scattering capacities of DelsaMax PRO to accurately size low concentrations of fullerene nanoparticles solubilized in toluene.

This application note demonstrates the ability of Beckman Coulter’s DelsaMax Core to determine the molecular weight, shape and polydispersity of a hexameric protein. The system can measure molecular weight between 300 and 10E6 Da and particle size between 0.4 and 10.000 nm at sample volumes as low as 1.25 μL.

The study described in this application note demonstrates how accurately the DelsaMax CORE instrument can determine the molecular weight of monoclonal antibodies and common proteins.

This application note highlights how the Beckman Coulter Optima MAX-XP ultracentrifuge was used to effectively reduce the time to remove the aggregated nanotubes, while the Vi-CELL XR from Beckman Coulter quantified cell toxicity in the presence of single-walled carbon nanotubes.

Understanding the experimental properties and thermodynamics of detergent solutions is important for the cleaning industry, basic encapsulation research, and increasingly, in protein studies. This application note demonstrates how the DelsaMax CORE accurately determined the hydrodynamic size of Sodium Dodecyl Sulfate micelles, a representative surfactant. The measurements in this work all took just a few minutes thanks to the state-of-the-art dynamic light scattering detection system on the DelsaMax CORE.

Bubbles create major issues when characterizing nanoparticles in solution because the characterization techniques typically utilize light scattering, specifically when determining size distribution and stability. Bubbles are much larger than nanoparticles and will scatter exponentially more light while interfering with particle movement, giving inaccurate results. This application note describes how the DelsaMax ASSIST can prevent these issues when using light scattering techniques.

This application note demonstrates the ability of Beckman Coulter’s DelsaMax Core to determine the molecular weight, shape and polydispersity of a hexameric protein.

This application note presents a simple workflow using automation, centrifugation and dynamic light scattering (DLS), to purify and analyze exosome samples. The Biomek 4000 laboratory automation workstation and the Optima MAX-XP ultracentrifuge provide a consistent, reproducible and high-throughput method for exosome analysis.

Carbon nanotubes are an emerging material that has had increasing industrial application in material reinforcement and great future potential in electronics, energy storage and conversion, and medicine. This application note demonstrates successful use of the DelsaMax PRO (Beckman Coulter) to measure the size and stability of single-walled carbon nanotubes (SWCNTs)/double-walled carbon nanotubes (DWCNTs) in aqueous solutions as a function of temperature.

In this video Matt Rhyner, Global Particle Characterization Business Manager for Beckman Coulter Life Sciences, introduces the DelsaMax family of particle analyzers. Matt tells SelectScience how the DelsaMax instruments are able to measure the size and zeta potential of nanoparticles with groundbreaking speed and high precision. Matt discusses some of the key features of the DelsaMax PRO including, its photodiode detector and 31 independent photodetectors, which reduce analysis time and improve accuracy, the DelsaMax Assist module to eliminate bubbles and the easy-to-use injection port.