Beacon® Optofluidic System
Understand the Life of Single Cells. The Beacon system unites optics, fluidics, and imaging to deliver high‑parameter, real‑time functional analysis of up to 60,000 live single cells. With automated scalability and downstream recovery, it accelerates therapeutic antibody discovery, vaccine development, immune profiling, cell therapy, and cell line development.
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The Beacon optofluidic system revolutionizes single cell research by integrating advanced optics, fluidics, and imaging to deliver large-scale, high-parameter, real-time functional characterization of live single cells. Unlock unprecedented insights in therapeutic antibody discovery, AI-driven antibody engineering, vaccine development, cell line development, and cell therapy innovation—all with unparalleled automation and speed.
The Beacon system accelerates large scale discoveries in antibody development, vaccine development, immune monitoring, cell therapy, and cell line development. It is an essential tool for biopharma therapeutic antibody discovery groups, autoantibody academic research, and top-tier CROs or CDMOs advancing next-generation drug discovery.
Key Benefits:
- Exquisite Control – Build your own single cell experiments with unparalleled precision
- Highest Parameters on Chip – Conduct real-time imaging for serial multi-modal analysis on the same live cells
- Infinite Possibilities off Chip – Identify and recover high-value cells to link on-chip phenotypic data with downstream sequencing
- Automated Scalability – Analyze 500 to 60,000 single cells enabling analysis of precious clinical samples or performing high throughput screening
Key Applications:
- Antibody Discovery
- Vaccine Response Profiling
- Cell Line Development
- T Cell Profiling and TCR/CAR Discovery
- Tumor-Infiltrating Lymphocyte (TIL) Characterization
- Cell Therapy Development and Validation
- Translational Biomarker Discovery
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Talk to a Bruker specialist to explore how live single-cell functional analysis and the Beacon platform can elevate your research.
Brochures
Opto cell line development workflow on the Beacon platform
Cell line development (CLD) teams need to identify productive, stable clones without allowing lengthy screening and expansion workflows to delay the progression of promising protein therapeutics.
This brochure introduces the Opto® Cell Line Development workflow on the Beacon® platform, covering single-cell cloning, monoclonality assurance and early assessment of productivity and product quality. It also outlines approaches for compressing development timelines, characterizing clones through a broad assay portfolio, and creating reproducible, automated workflows.
Discover how Opto® CLD can help teams select promising production clones earlier, reduce downstream screening requirements, and shorten the route from transfection to lead clone selection.
Resource details:
Resource type: Product brochure
Page count: 5 pages
Read time: 8 mins
Accelerating cell line development with selective single-cell cloning
Cell line development workflows must balance two competing priorities: shortening the time needed to isolate production clones and identifying cells capable of delivering high recombinant protein productivity.
This whitepaper investigates a combined cloning strategy using low-viability Chinese hamster ovary (CHO) cell pools, cold-capture staining and the Beacon® Optofluidic System. Researchers evaluated the approach across three antibody formats to determine whether early cloning and fluorescence-based enrichment could accelerate clone selection while improving titer and clone-specific productivity.
Discover how selective single-cell cloning can focus screening capacity on promising producers, reduce cell line development timelines, and support the identification of highly productive CHO clones. The study reports that using low-viability pools shortened the workflow by two weeks, while combining early sorting with cold-capture enrichment produced clones with higher productivity than the conventional workflow tested.
Resource details:
Resource type: Whitepaper
Page count: 10 pages
Read time: 15 mins
Identify top producing clones with favorable product quality attributes for diverse protein therapeutics using Opto CLD
Developing complex protein therapeutics requires more than identifying the fastest-growing or highest-producing clones. Product quality and manufacturability must also be assessed early to avoid expanding unsuitable candidates through lengthy rounds of cell line development.
In this study, discover how Opto® Cell Line Development (CLD) enables high-throughput screening of individual clones using productivity and product quality measurements. Through workflows involving monoclonal antibodies and other protein formats, the study also demonstrates how early functional characterization can help identify promising clones from diverse populations.
Learn how combining clone selection with early product quality assessment can improve cloning efficiency, shorten development timelines and support the selection of manufacturable protein therapeutics.
Resource details:
Resource type: Application note
Page count: 12 pages
Read time: 18 mins
Beacon Optofluidic System
In this poster, Berkeley Lights presents its Beacon Optofluidic System for antibody discovery, cell line development, and cell therapy development.
Berkeley Lights: Antibody discovery
Here, Berkeley Lights presents its antibody discovery workflow.
Opto CLD: The new standard for quality, capacity, and speed in cell line development
Here, Berkeley Lights presents its workflow for cell line development.
Berkeley Lights: Cell line development
Discover Berkeley Lights' workflow for cell line development.
FDA-accepted monoclonality assurance on the Beacon Optofluidic System for cell line development
In this application note, Berkeley Lights presents its Beacon® Optofluidic System for cell line development.
Rapid generation of production cell lines with superior titers and >99% monoclonality for complex antibody molecules
In this poster, Berkeley Lights presents how its Beacon Optofluidics Platform was utilized for the rapid generation of production cell lines with superior titers and >99% monoclonality for complex antibody molecules.
How to get to market faster with Opto cell line development
In this datasheet from Berkeley Lights, discover how to get to market faster with Opto™ cell line development.
Catalent Biologics on cell line development
Here, Catalent Biologics describe how it utilized the Beacon® optofluidic system from Berkeley Lights for cell line development.
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Beacon® Discovery™ Optofluidic System
Bruker Cellular AnalysisLive Single Cells. Deepest Functional Insights. Beacon Discovery enables real‑time, multimodal functional analysis of thousands of live single cells, linking dynamic assays to sequencing from the same cell. Its compact, cost‑effective platform supports T‑cell profiling, cell therapy development, and antibody discovery.