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Opto cell line development workflow on the Beacon platform

Bruker Cellular Analysis
14 Sept 2026

Cell line development (CLD) teams need to identify productive, stable clones without allowing lengthy screening and expansion workflows to delay the progression of promising protein therapeutics.

This brochure introduces the Opto® Cell Line Development workflow on the Beacon® platform, covering single-cell cloning, monoclonality assurance and early assessment of productivity and product quality. It also outlines approaches for compressing development timelines, characterizing clones through a broad assay portfolio, and creating reproducible, automated workflows.

Discover how Opto® CLD can help teams select promising production clones earlier, reduce downstream screening requirements, and shorten the route from transfection to lead clone selection.

Resource details:

Resource type: Product brochure
Page count: 5 pages
Read time: 8 mins

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Beacon® Optofluidic System

Bruker Cellular Analysis

Understand the Life of Single Cells. The Beacon system unites optics, fluidics, and imaging to deliver high‑parameter, real‑time functional analysis of up to 60,000 live single cells. With automated scalability and downstream recovery, it accelerates therapeutic antibody discovery, vaccine development, immune profiling, cell therapy, and cell line development.

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Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Line DevelopmentCell AnalysisThe analysis of cells allows researchers to understand the factors which contribute to cell health and function. These influencing processes can then be predicted and altered, leading to the development of medication and disease treatments.Cell Lines

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