ResourceDrug Discovery & Development
Eliminating blind spots in drug discovery and development
22 Sept 2026This case study demonstrates how Inotiv used an integrated transcriptomics-to-Adverse Outcome Pathway (AOP) approach to transform complex omics data into actionable toxicology insights. Learn how advanced bioinformatics, statistical validation and mechanistic pathway analysis were applied to investigate drug-induced testicular injury and to identify early indicators of reproductive toxicity. Discover how the approach enabled the identification of 222 relevant AOPs, pinpointed specific risks of reproductive failure, and supported more informed go/no-go decisions during early-stage drug development.
Resource details:
Resource type: Case study
Page count: 3
Read time: 5 mins
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ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BioinformaticsBioinformatics uses computational models and methodologies to study biological processes and to understand biological data.