Beacon® Discovery™ Optofluidic System
Live Single Cells. Deepest Functional Insights. Beacon Discovery enables real‑time, multimodal functional analysis of thousands of live single cells, linking dynamic assays to sequencing from the same cell. Its compact, cost‑effective platform supports T‑cell profiling, cell therapy development, and antibody discovery.
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Experience the full potential of live single cell functional analysis with Beacon Discovery. Powered by optofluidic technology, it enables researchers to explore multimodal and temporal cellular responses in real time, seamlessly linking functional data to sequencing from the same single cell for deeper scientific breakthroughs.
This accessible, compact, and flexible platform, with lower cost of ownership, delivers unparalleled insights into immune profiling, cell therapy, and antibody discovery. Whether identifying potent T cells, TILs, NK cells, or discovering high-affinity antibody-secreting B cells for challenging targets, Bruker Cellular Analysis's Beacon® portfolio delivers the deepest functional insights from live single cells.
With the ability to screen thousands of live T cells and perform multiple functional assays per cell, including dynamic cytotoxicity, cytokine secretion, cell surface marker expression, scientists can comprehensively evaluate T cell potential in context and connect it with TCR-seq and transcriptomics data from the same single cells. For antibody discovery, this includes running multimodal functional assays, such as antigen specificity, cross-reactivity, affinity, membrane-bound antigen cell-binding, ligand blocking, and internalization, on tens of thousands of single B cells. The most promising antibody-secreting cells can be directly exported and sequenced, enabling a truly end-to-end antibody discovery workflow with a single platform.
Key Benefits:
- Exquisite Control: Build your own single cell experiments with unparalleled precision
- Live Cell Imaging: Capture real-time behaviors like biomolecule secretion, target killing, cell-cell interaction, and antigen binding
- Highest Parameters: Conduct multiple sequential assays on the same live single cells across hours or days
- Multiomics Connectivity: Identify and recover high-value cells to link phenotypic insights with downstream genomics and transcriptomics (TCR-seq, BCR-seq, mRNA-seq)
- Automated Scalability: Analyze 500 to 20,000 single cells, enabling analysis of precious clinical samples or performing high throughput screening
- Accessible and Cost-Effective: Empower low cost of ownership, compact benchtop footprint, and easy-to-use intuitive interface
- Flexible Workflows: Supports end-to-end pre-defined workflows and custom assay protocols for broad research applications
- Proven Technology: Built on Bruker Cellular Analysis's widely published, validated optofluidic platform
Key Applications
- T Cell Profiling and TCR/CAR Discovery
- Tumor-Infiltrating Lymphocyte (TIL) Characterization
- Cell Therapy Development and Validation
- Translational Biomarker Discovery
- Antibody Discovery
- Antibody Profiling
- Vaccine Response Profiling
Ready to See What's Possible?
Talk to a Bruker specialist to explore how live single-cell functional analysis and the Beacon Discovery can elevate your research.
Powering deepest functional insights from live single cells with Beacon Discovery
May 20, 2025 17:00 BST / 18:00 CEST / 12:00 EDT / 09:00 PDT
Single-cell functional analysis is essential for uncovering the behavior of individual cells. It complements cellular transcriptomics analysis by providing critical insights that empowers researchers to discover complex biological processes and diseases.
Join our live webinar with two experts, Dr. Joseph Zenga, MD, and Dr. Alireza Salmanzadeh, MBA, PhD, as they introduce Beacon Discovery™, a flexible and accessible solution for temporal functional cellular analysis powered by proven Opto-Electro Positioning (OEP®) technology. Learn how Beacon Discovery facilitates advanced single-cell analysis with multi-dimensional data and sequential assays, and supports scalable and efficient workflows to drive breakthroughs in cell therapy, antibody discovery, vaccines, and beyond.
Plus, Dr. Zenga will share how he has used this platform to push the boundaries of T-cell profiling and CAR/TCR discovery, opening new possibilities for cancer immunotherapy.
Key learning objectives
- Learn how to rapidly identify functional CARs and TCRs to use as cell therapy candidates, and how to simultaneously collect cytokine, surface phenotype, and cytotoxicity data for individual cells for T-cell profiling
- Learn how to find rare targets faster, and discover many more functional hits than hybridoma, and profile antibody repertoire to characterize vaccine performance
- Learn how to perform real-time sequential multiplexed assays to capture dynamic cellular behaviors, and how to link live-cell functional analysis with genomic and transcriptomic data from the same single cell for deeper insights
- Gain expertise in immune profiling, long-term cell culturing, cell-cell interaction, and high-throughput screening to accelerate translational research
Who should attend?
- Researchers interested in assessing the function of single cells
- Researchers working on T cells, cell therapy, and CAR/TCR discovery and antibody discovery
- Academic, biotech, and pharmaceutical professionals
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
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Beacon® Optofluidic System
Bruker Cellular AnalysisUnderstand the Life of Single Cells. The Beacon system unites optics, fluidics, and imaging to deliver high‑parameter, real‑time functional analysis of up to 60,000 live single cells. With automated scalability and downstream recovery, it accelerates therapeutic antibody discovery, vaccine development, immune profiling, cell therapy, and cell line development.