Astec CHIROBIOTIC™ V2 Chiral HPLC Column
The polar organic and the polar ionic modes have become increasingly popular largely because of their ideal compatibility with MS detection and preparative LC. Two years of extensive research at Astec in understanding these mechanisms has resulted in new possibilities for extending their effectiveness even further. Important changes in linkage chemistries and the silica and the silica have now led to the new CHIROBIOTIC V2 and…
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The polar organic and the polar ionic modes have become increasingly popular largely because of their ideal compatibility with MS detection and preparative LC. Two years of extensive research at Astec in understanding these mechanisms has resulted in new possibilities for extending their effectiveness even further. Important changes in linkage chemistries and the silica and the silica have now led to the new CHIROBIOTIC V2 and T2 chiral stationary phases – columns of choice for those really difficult separations, and especially, for preparative LC.
These new phases extend the capabilities of the series. They are designed to be used in the optimization process since they offer some distinct advantages in the polar ionic mode and polar organic mode. The standard CHIROBIOTIC phases remain the columns of choice for method development screening and for reversed phase separations.
Read about the Astec CHIROBIOTIC being applied to Drug testing for Amphetamine and Methamphetamine Abuse here.
Features:
- New extension for the CHIROBIOTIC series
- Enhanced selectivity and capacity in the polar organic mode and polar ionic mode
- Capacity increases of 2 to 20 fold over standard CHIROBIOTIC phases
- Most beneficial for basic molecules
- Neutral molecules can often be run in pure methanol
Accurate Biological Testing for Amphetamine and Methamphetamine Abuse
This application note is an application newsletter from Sigma Aldrich which looks at the many applications of LC/MS, both in research and clinical use. The application note shows the features of many different pieces of equipment including the Astec® CHIROBIOTIC® V2 which can be found on the SelectScience website here.
SUPELCO® Application Compendium: Forensic, Clinical and Bioanalytical Applications
This application compendium presents a series of technical articles covering forensic, clinical, and bioanalytical applications. Topics include SPME of VOCs in Breath, Analysis of Vitamin D Metabolite Critical Pairs in Serum, Chiral LC-MS of Methamphetamine, and more.
Chiral LC-MS Analysis of Methamphetamine in Urine on Astec CHIROBIOTIC V2
D-Methamphetamine is an illegal substance abuse recreationally and in sorts doping. Its enantiomer, L-Methamphetamine, is legal and found in several common medications. Reliable analytical methods to clearly distinguish the D- and L- forms are therefore necessary to prevent false positives in clinical or forensic settings. LC-MS has become an important tool for this purpose. Astec®CHIROBIOTIC® V2 efficiently separates methamphetamine enantiomers using LC-MS-compatible conditions allowing sensitive differentiation of the D- and L- forms in urine.
Determination of L- and D-Lactic Acid Enantiomers by LC-MS
Errors in lactic acid metabolism affect the ratio of L- and D-isomers causing certain neurological disorders. Chiral LC-MS using Astec® CHIROBIOTIC®R provides a rapid, simple, and reproducible method for clinical routine detection of L- and D- lactic acid.
Chiral LC-MS of D- and L-2-Hydroxyglutaric Acid Biomarkers
Chiral 2-hydroxyglutarates are important molecular signatures of their specific biochemical pathways and inborn errors of metabolism. The ability to distinguish the enantiomers of 2-OHG is important to be able to track its disposition throughout the metabolic pathway of normal vs. mutated cells. Astec® CHIROBIOTIC® columns provide necessary enantioselectivity, and have the advantage of operating in aqueous and polar organic mobile phases that are amenable to polar analytes and metabolites.
