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Premium Shipping Containers for Premium Research Models.
SAGE® Labs now offers plastic containers, developed for shipping your research models more safely. These containers are sturdier than cardboard boxes, for excellent protection a... Read more...
In vivo model for xenograft and Immunology studies.
Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules du... Read more...
The Prkdc gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK).
DNA-PK is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. ... Read more...
In vivo model for cardiovascular, alzheimer’s and other neurodegeneration studies.
Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ... Read more...
The Low-Density Lipoprotein (LDL) receptor is directly involved in the development of atherosclerosis, due to accumulation of LDL cholesterol in the blood. Ldlr (-/-) rats show elevated serum cholesterol levels.
Ldlr Knockout Rat Char... Read more...
Leptin is essential for energy intake and expenditure.
It is one of the most important adipose-derived hormones, being primarily expressed in adipocytes of white adipose tissue. Loss of function of Leptin creates an uncontrolled appet... Read more...
Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making i... Read more...
Cyclooxygenase (COX), also known as prostaglandin synthase (PHS) and prostaglandin endoperoxide synthetase (PES), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins... Read more...
Galectins have been implicated in inflammation and cancer, and are useful targets for development of new anti-inflammatory and anticancer therapies. LGALS1 (GAL1) may act as an autocrine negative growth factor that regulates cell prolifera... Read more...
T-box transcription factor (TBX21) is a member of the T-box protein family, which shares a common DNA-binding domain. TBX21 plays a critical role in Th1 cell differentiation through stimulation of IFN γ.
Due to a hypersensitive immune s... Read more...
This model contains a bi-allelic deletion within the peroxisome proliferator-activated receptor alpha gene (Ppara).
Ppara Knockout Rat Characteristics:
Homozygous Knockouts exhibit complete loss of protein via Western blot
... Read more...
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase.
Mutations in Pink1 are implicated in ear... Read more...
This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein.
A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish fa... Read more...
This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger’s syndrome.
This model is useful for understanding the role of neuroligins in the development of a... Read more...
This model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons.
This model possesses a targeted insertion of (IRES)-cre immediately after the... Read more...
Colony Expansion and Custom Breeding Services
SAGE® Labs offers continued support for your custom model generation needs. Whether it’s breeding a small cohort of homozygous knockouts for characterization or expansion for regular cohor... Read more...