Building better organoids with advanced culture, imaging and analysis

Find practical guidance, technologies and expert insights to help you build more reproducible, physiologically relevant models

Organoids are transforming the way researchers study human biology.

These advanced 3D cell models recreate key features of human tissues and organs, providing a more physiologically relevant way to investigate development, disease, and therapeutic response than traditional 2D cell culture.

Derived from stem cells and grown under carefully controlled conditions, organoids can model tissues including the brain, liver, lungs, and gut. Their growing use across disease modeling and drug discovery is driving demand for more reproducible and scalable organoid development workflows. Advances in organoid culture, automation, bioprinting, high-resolution imaging, and data analysis are now helping researchers generate, characterize, and analyze increasingly sophisticated models.

This feature explores the latest advances in organoid development and analysis, from innovative culture methods and bioprinting to advanced organoid imaging, functional assays, and multiomics. Discover expert insights, technologies, and workflows helping researchers build better organoid models, study disease biology, accelerate drug discovery, and advance personalized medicine.

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Want to explore automating your own organoid workflows?

Discover how the Lions Eye Institute in Perth, Australia, is harnessing Tecan automation to transform iPSC and retinal organoid research. In this video, Senior Scientist Sam McLenachan shares how the Stem Cell Robot System integrates automated liquid handling, imaging, and incubation to streamline stem cell reprogramming, retinal cell differentiation, and high-throughput drug screening.

Explore how this technology enabled the institute’s largest-ever drug screen, testing 283 antioxidant compounds for RCBTB1-associated retinopathy, and see what automation could make possible for your own organoid workflows.

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Brain organoids and MEA tech reveal new epilepsy mechanisms

Discover how Prof. Robert Halliwell from the University of the Pacific is combining 3D brain organoids with MEA technology to uncover new insights into epilepsy. Explore how real-time neural activity monitoring is advancing disease modeling and drug discovery. 

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Choose the best cell imaging technology for your lab

Get practical guidance and expert insights on selecting the right cell imaging technologies, with real-world applications to help monitor cell health, analyze complex 3D cell models, and improve accuracy, reproducibility, and efficiency.

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Organ-Chips reach new frontiers with AVATAR and next-gen preclinical testing

Learn how Dr. Lorna Ewart and Dr. David Benson Chou from Emulate are advancing Organ-on-a-Chip technology for scalable preclinical testing and NASA’s AVATAR mission, unlocking new insights into human biology and drug development.

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High-throughput organoid screening at scale with automated liquid handling

Learn how Peter van Schaik of Crown Bioscience is using SPT Labtech’s firefly® automated liquid handling platform to overcome challenges in organoid screening. Discover how automation is enabling scalable, high-throughput workflows to accelerate drug discovery.

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Build smarter, more scalable cell culture workflows

Gain practical insights into selecting the right cell culture technologies, integrating automation, and optimizing 2D and 3D workflows. Find expert tips and best practices to enhance reproducibility, streamline laboratory processes, and make more informed technology decisions.

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