Using UPLC-MS/MS for Workplace Drug Testing

ACQUITY UPLC® BEH C18 and C8 columns were designed to be the universal columns of choice for most UPLC® separations by providing the widest pH range.They incorporate trifunctional ligand bonding chemistries which produce superior low pH stability and ultra-low column bleed. This low pH stability is combined with the high pH stability of the 1.7 µm BEH particle to deliver the widest usable pH operating range. In addition, these new chemistries also utilize new, proprietary endcapping processes which produce outstanding peak shape for bases. These bonding chemistries and particle synthesis innovations produce the sharpest peaks, highest efficiencies and maximum MS sensitivities.

The TargetLynx™ Application Manager automates sample data acquisition, processing and reporting for quantitative results.It incorporates a range of confirmatory checks that identify samples that fall outside user-specified or regulatory thresholds. Identify Non-compliant Samples TargetLynx rapidly identifies and flags samples where: Analytes are above a specified maximum reporting level (MRL) Analyte confirmatory ion ratios are outside specified limits One or more analyte signal-to-noise ratios are below a defined value An analyte retention time or relative retention time is outside limits An analyte concentration is below set LOD and LOQ thresholds The standard deviation of response for QC standards exceeds a defined value The blank response is too high The coefficient of determination (r2) of the calibration curve exceeds a defined value LC/MS & LC/MS/MS and GC/MS & GC/MS/MS Use TargetLynx to quantify and confirm both LC/MS & LC/MS/MS and GC/MS & GC/MS/MS data. This data may be selected ion monitoring (SIM), multiple reaction monitoring (MRM), or full scan/full spectrum. In the case of full scan/spectrum data, extracted ion chromatograms are used for quantification. Ensure Regulatory Compliance The demand by regulatory authorities for assurance of confirmation in quantitative analysis continues to increase. To ensure cost-effective compliance, TargetLynx offers software that gives you confidence in your results and eliminates time-consuming, costly manual checks.

Information-rich, robust quantitative data, accessible to everyone.