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This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain... Read more...
In vivo model for xenograft and Immunology studies.
Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules du... Read more...
The Prkdc gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK).
DNA-PK is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. ... Read more...
In vivo model for cardiovascular, alzheimer’s and other neurodegeneration studies.
Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ... Read more...
Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making i... Read more...