TechTalk: Analytical HPLC strategies across the nucleic acid therapeutics landscape – From ASOs to siRNA to mRNA
Friday, October 9 at 16:00 BST | 17:00 CEST | 11:00 EDT | 08:00 PDT
Nucleic acid therapeutics such as antisense oligonucleotides (ASOs), siRNA, and mRNA present unique analytical challenges due to their diverse sizes, chemistries, and structural complexities.
In this TechTalk we will explore HPLC-based strategies for the characterization of these emerging therapeutic modalities, highlighting molecule-specific analytical approaches and practical application examples. Particular emphasis will be placed on the use of YMC Accura Triart columns for ion-pair reversed-phase (IP-RP) separations and YMC Accura BioPro IEX columns for anion-exchange (AEX) chromatography.
You will gain an understanding of the key analytical challenges associated with different nucleic acid therapeutics, and will learn how IP-RP and AEX chromatography can be applied to address different analytical questions across the nucleic acid therapeutics landscape.
Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.
TechTalk details
- Cost: Free to attend
- Location: Online
- Duration: 20 minutes
Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on-demand recording once it becomes available.
Speakers
Who should attend?
- Analytical development scientists
- Analytical lab heads/managers
- PhD students in analytical sciences
- Post docs in analytical sciences
Featured products
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Robust bioinert columns for a new level of recovery: YMC Accura BioPro IEX columns
YMC EuropeBioinert coated YMC Accura BioPro IEX columns provide excellent peak shapes for sensitive compounds, ensuring high recovery from the very first injection.
(Bio)inert RP/HILIC (U)HPLC Columns: YMC Accura Triart
YMC EuropeBioinert YMC Accura Triart RP and HILIC columns are available for the analysis of critical substances including selected proteins, (oligo)nucleotides and metal-coordinating compounds such as organophosphates.
What will this webinar cover?
- The analytical challenges associated with ASOs, siRNA, and mRNA.
- How to select appropriate HPLC strategies for the characterization of different nucleic acid therapeutics.
- How HPLC methods can be adapted to molecule-specific analytical requirements.
