Top List: Trends in Cryo-EM: How cryo-electron microscopy technology is revolutionizing the drug discovery industry

Discover the latest advances and top resources in cryo-EM, from elucidating protein structure to single particle analysis reconstruction

19 Feb 2020

Electron microscopy (EM) is used to create high-resolution images of samples at the nanoscale, using an accelerated beam of electrons as a source of illumination. Cryo-EM is used to view samples prepared under cryogenic conditions and is becoming an essential technology within many fields, especially structure-based drug discovery. In this article, we take a closer look at some of the latest advancements and applications of cryo-EM technology within the pharmaceutical industry. Plus, 2017 Nobel Prize winner in chemistry, Dr. Richard Henderson, highlights just how important cryo-EM is within science as a whole.

2017 Nobel laureate in chemistry, Dr. Richard Henderson

Learn how AstraZeneca is adopting cryo-EM to expand its targets for drug discovery

In this article, Dr. Chris Phillips, structural biologist and Associate Director at AstraZeneca, discusses how cryo-EM might be a ‘game-changer’ for elucidating protein structure where current conventional crystallographic approaches fall short. 
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Discover the impact of cryo-EM on pharma 

In this exclusive interview for The Scientists’ Channel, watch Dr. Richard Henderson, 2017 Nobel Prize winner in chemistry, discuss the growing importance of cryo-electron microscopy for science and how leading pharmaceutical companies are working together to utilize this revolutionary technique at the newly opened Cryo-EM suite at eBIC at Diamond Light Source, Harwell Science and Innovation Campus.
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Meet one of the first cryo-EM groups set on delivering a resolution revolution

In this SelectScience interview, we talk with Dr. Claudio Ciferri, structural biologist, crystallographer and head of cryo-EM at Genentech, about drug discovery through investigation of the structure and function of challenging protein targets. Ciferri explains how the use of cryo-EM is enabling his team to tackle many targets that are otherwise impossible to visualize. 
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eBook: Applications of cryo-EM in structure-based drug discovery

In this application-based eBook, we outline the application of cryo-EM in structure-based drug discovery and look at how state-of-the-art microscopes, such as the Krios G4 cryo-TEM from Thermo Fisher Scientific, help to keep leaders in the pharmaceutical industry at the forefront of drug discovery.
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Why invest in cryo-EM?

In this application note, Thermo Fisher Scientific highlights how your lab could benefit from using cryo-EM technology.
Download here>>

Related cryo-EM resources:

  • Applications of cryo-electron microscopy: Explore the versatility of cryo-EM and the variety of benefits made possible by this method and discover how cryo-EM provides enhanced insight into all classes of biomolecules, including proteins that are difficult to work with. Download here>>
  • Practical recommendations for cryo-EM single-particle analysis reconstruction: In this application note, Thermo Fisher Scientific details the main principles of image processing for single particle analysis (SPA) and details practical solutions to this rapidly evolving computational landscape. Download guide>>
  • Sample preparation for cryo-EM: A step-by-step guide to the requirements for sample preparation in cryo-electron microscopy (cryo-EM) to ensure the collection of high-resolution data. Download guide>>

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Find out more about Thermo Fisher Scientific's cryo-EM tools for drug discovery>>