Introduction to Solvent Evaporation

11 Apr 2018

Solvent removal is an essential process for sample preparation across a range of applications in many industries. Many sample formats and solvents are used with no single technique providing a universal solution, but despite the variety of specifics evaporation is well-understood and relatively uncomplicated.

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Sample Genie
Genevac
SampleGenie technology, in conjunction with Genevac Rocket Synergy, HT and EZ-2 series evaporators, enables large sample volumes to be dried directly into vials, eliminating a number of time-consuming sample handling steps and the attendant risk of errors. Traditionally protocols for concentration of chromatographic fractions has involved drying multiple fractions in an evaporator, re-suspending and pooling fractions into a single vial and then re-drying before storage and analysis. Even with modern centrifugal evaporators such processes typically take 2-3 days to complete. Using SampleGenie pooled fractions can be dried directly into the final submission vial, reducing the process time by up to 66%. Available for starting volumes of up to 60ml, 125ml and 250ml, SampleGenie is compatible with a wide range of HPLC, GC and storage vial sizes.
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Series 3 HT Evaporator
Genevac
The all new Series 3 HT evaporator range from Genevac represents the ultimate in solvent removal technology. The latest touchscreen technology, new high performance vacuum pump, and a sleek ergonomic design makes optimising your evaporation processes effortless. High speed, High throughput evaporation Front opening for easy access. New intuitive touchscreen control system for ultimate ease of use Integral condenser meaning a smaller system footprint Rugged design with clean lines and a modern look All the features and functionality you expect from a Genevac HT evaporator including Dri-Pure anti-bumping, automatic end of run, HCl resistance, Inert Gas Purge, Lyospeed and EXALT controlled crystallisation Available in HT-6 and HT-12 format, Series 3 HT evaporators feature a new 6 place rotor which accepts all existing Genevac HT series holders. Sample formats include microtitre plates, tubes, vials, flasks and SampleGenie - unique flask and sample holder technology which enables large volume samples to be dried or concentrated directly into the small vial of your choice. Intuitive touchscreen controls enhances monitoring and review of the whole evaporation process. For popular solvent removal protocols pre-set 'Press & Go' methods makes operation easy and productive even for occasional users. Simplified manual and automatic programming means even the most complex multi-stage evaporation methods can be set-up and run quickly and easily. Genevac HT Evaporators are designed to provide the ideal solution for evaporation bottlenecks in the drug discovery laboratory. High performance and high sample capacities make them the ideal workhorses for the busy medicinal chemistry laboratory. Applications: High Throughput Chemistry and Parallel Synthesis LC/MS or HPLC Purification Fast Lyophilisation of purification fractions Natural Products Research Oligosynthesis Flash Chromatography Process Development.
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Rocket 4D Synergy Large Volume Evaporator
Genevac
Rocket 4D Synergy is designed primarily to evaporate large sample volumes, with autofeed if required, allowing automatic evaporation of volumes up to 100 litres. Rocket 4D Synergy provides fast, safe evaporation for solvents with a boiling point of up to 165°C (DMF) and can easily dry aqueous samples. The system feeds the solution for evaporation to the evaporation vessel, controls temperature and pressure, prevents bumping and foaming, drains the condenser, stops when dry or concentrated, and if required, redissolves the product in a small volume of solvent, unattended, and with no user intervention. The Rocket 4D Synergy can also be fitted with a removable flask rotor to accommodate the full range of Rocket Sample handling solutions such as flasks, tubes and SampleGenie. Now you don't need to choose between flask or batch/feed evaporation. The Rocket and Rocket 4D Synergy evaporators will accommodate your process, whatever the volume. Each is capable of replacing several rotary evaporators and saving valuable bench space.
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Rocket Synergy Evaporator
Genevac
Rocket Evaporators use patented vacuum technology to evaporate solutions to dryness, or a concentrate, rapidly and safely. The latest Synergy series offers integrated, flexible solutions for processing a wide range of sample volumes. Interchangeable rotors will accommodate tubes, flasks and batch volumes of up to 100L. Rocket Synergy is designed primarily to quickly process larger volumes of solvent in parallel and without supervision. The Rocket Synergy Evaporator will accommodate six flasks, each containing up to 450ml of solvent, as well a variety of innovative Genevac sample holders such as the SampleGenie. The removable rotor may also be replaced with a 5L 316 stainless steel vessel for batch processing. Now you don't need to choose between flask or batch/feed evaporation. The Rocket and Rocket 4D Synergy evaporators will accommodate your process, whatever the volume. Each is capable of replacing several rotary evaporators and saving valuable bench space.
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EZ-2 Series
Genevac
Using the most advanced proven technology in evaporation science, the third generation of the EZ-2 Series has been designed specifically for solvent removal in life science research; be that concentration of samples or complete drying. The innovative design of the EZ-2 Series presents many advantages for working in parallel within synthesis chemistry, analytical sample preparation and for general-purpose solvent removal needs in life science laboratories. At the heart of the evaporator is a solvent resistant, oil-free vacuum pump, and the high efficiency, defrost-free, SpeedTrap™, which traps all solvents as liquids, even water. Solvents collect in the insulated, plastic coated glass vessel, enabling the user to see the progress of evaporation and determine when the trap should be emptied. The EZ-2 Elite has a special auto-draining collection vessel fitted to the SpeedTrap, which uses the very powerful Scroll pump. The Elite can therefore evaporate the highest boiling solvents such as DMSO and perform the Genevac LyoSpeed fast lyophilisation method for HPLC fractions. There is a low-cost option available on the Standard, Plus and Elite that allows the routine use of hydrochloric acid and aggressive solvents. By building key elements in Hastelloy®, glass or PTFE, full protection against acid chlorides is achieved. New to the HCl Resistance option is the ability to evaporate concentrated nitric acid. This option must be specified when ordering, as it cannot be retrofitted. All EZ-2 models are resistant to routine use of high concentrations of TFA as standard. An additional option is available to allow safe operation for those wishing to use highly explosive solvents, such as pentane or diethyl ether - the inert gas purge system. This system can also be used to preserve oxygen or moisture sensitive samples under an inert gas blanket until the user returns to the evaporator. The EZ-2 Series can also accommodate a wide selection of sample holders, including round-bottom flasks up to 500ml, tubes up to 160mm long (including Dionex ASE® and Radleys Carousel tubes), custom reaction blocks, and shallow or deep-well microtitre plates. EZ-2 Series Models: The Standard (EZ-2) is suitable for water and volatile solvents The Envi (EZ-2 Envi) is recommended for concentration of volatile solvents The Plus (EZ-2 Plus) is recommended for solvents with boiling points upto 165°C The Elite (EZ-2 Elite) is recommended for solvents with boiling points upto 220°C
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miVac DNA Concentrator
Genevac
The miVac DNA is an ideal small concentrator for the molecular biology laboratory. A centrifugal concentrator capable of removing water and organic solvents from a variety of sample formats including tubes, microplates and vials. Making it an ideal "work-horse" concentrator for the busy lab. The built-in special runs for working with water and water mixtures improve performance and optimise concentration time and make the miVac DNA ideal for applications requiring concentration of solvent from precious samples in: small scale oligo-synthesis, RNA/DNA prep., peptide prep., sequencing, molecular biology, and general academic/life science research.
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miVac Duo Concentrator
Genevac
The miVac Duo Concentrator is suitable for use with a wide range of solvents, from volatile organic solvents through to water and some of the higher boiling point solvents. The Duo is a centrifugal vacuum concentrator compatable for use with variety of sample formats including tubes, microplates, vials and round bottom flasks. Making it an ideal "work-horse" concentrator for the busy lab. Combined with a SpeedTrap and JetRotors miVac concentrators are the fastest in class.
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miVac Quattro Concentrator
Genevac
The miVac Quattro Concentrator is suitable for use with a wide range of solvents, from volatile organic solvents through to water and some of the higher boiling point solvents. The Quattro is a centrifugal vacuum concentrator compatable for use with variety of sample formats including tubes, microplates, vials and round bottom flasks. Making it an ideal "work-horse" concentrator for the busy lab. The Quattro has more than double the capacity of the Duo concentrator. Combined with a SpeedTrap and JetRotors miVac concentrators are the fastest in class.
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miVac Concentrators
Genevac
miVac is a range of centrifugal vacuum concentrators and freeze driers capable of removing water and organic solvents from a variety of sample formats including tubes, microplates, and vials. miVac concentrators come in 2 sizes, the smaller Duo and a larger Quattro. There is a choice of vacuum pump and rotor according to application and sample format. To speed concentration built-in special runs for working with water and water mixtures improve performance, helping optimise concentration time. The addition of the revolutionary SpeedTrap condenser to the system will greatly enhance concentration performance. miVac systems feature unique JetRotors - solid aluminium rotors which speed concentration manifold. An optional pressure control unit provides display of chamber pressure and manual or automatic control of the vacuum level. The miVac SpeedTrap can also be used for freeze drying when configured with a miVac Super vacuum pump, as a combined concentration / freeze drying workstation with a miVac vacuum concentrator or as a stand-alone freeze drier. Applications: Suitable for use with Oligo-synthesis, RNA/DNA prep., peptide prep., sequencing, molecular biology, ADME / toxicology labs, process development, residue analysis, environmental analysis and general academic/life science research.
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