Cross-species 3D liver models improve prediction of drug-induced liver injury

This whitepaper explores the use of cross-species 3D liver microtissues to improve prediction of drug-induced liver injury (DILI) during preclinical development. Using a case study, the work demonstrates how advanced in vitro models can reveal species-specific mechanisms of toxicity that are not captured using traditional animal models or short-term cytotoxicity assays.

By combining long-term exposure studies with functional and transcriptomic analysis, the models enable identification of complex toxicity pathways and support more accurate human risk assessment. The findings highlight the value of integrating 3D in vitro liver systems early in drug discovery workflows to reduce late-stage attrition and improve translational outcomes.

Resource details:

• Resource type: Whitepaper
• Page count: 12
• Read time: 20 mins