3D InSight mouse liver microtissue validation supports reproducible preclinical testing

This validation report from InSphero evaluates the performance of 3D InSight™ C57BL/6 mouse liver microtissues, confirming consistent morphology, viability, and functionality over a 28-day culture period. The co-culture model, composed of primary hepatocytes and non-parenchymal cells, demonstrates stable tissue structure and reproducible behavior across experimental conditions.

Functional testing, including albumin secretion, cytochrome P450 (CYP) enzyme activity, and drug-induced liver injury (DILI) assays, supports the model’s suitability for safety assessment and preclinical research. The results confirm that the validated cell lot meets performance criteria for use in liver toxicity studies and related applications.

Resource details:

• Resource type: Application note
• Page count: 21
• Read time: 34 mins