UHPLC and HPLC Products & Reviews

Designed to withstand 100% aqueous conditions and increased retention for polar molecules, InfinityLab Poroshell 120 Aq-C18 columns are the modern and reliable choice for HPLC and UHPLC separations. Now master your polar molecules, especially under water.  

100Å pore size, high ligand density;  available in 1.0, 2.0,  3.0, 4.6 and 10 mm ids;  30 - 250 mm lengths. Pursuit columns are ideal for pharmaceutical applications using LC/MS, from analyzing lead compounds and biological samples in drug discovery, to implementing dependable analysis of raw materials and approved drugs in the QC process.  Build on the large 200A pore size silica, high liquid density delivers up to 40% faster…

The 1290 Infinity III Evaporative Light Scattering Detector (ELSD) is ideal for reproducible, sensitve detection of both volatile and nonvolatile compounds that cannot be detected by UV. A unique peltier cooled evaporator coupled with an original gas flow design allow subambient operation down to 10 °C. This delivers maximum sensitivity for compounds with significant volatility below 30 °C.

200A pore size;  available in 3.0 and 4.6  mm ids, and lengths from 50 - 250 mm. Pursuit columns are ideal for pharmaceutical applications using LC/MS, from analyzing lead compounds and biological samples in drug discovery, to implementing dependable analysis of raw materials and approved drugs in the QC process.  Build on the large 200A pore size silica, high liquid density delivers up to 40% faster separations without sacrif…

Agilent Bio-Monolith HPLC columns provide high resolution and rapid separations of antibodies (IgG, IgM), plasmid DNA, viruses, phages and other macro biomolecules. The product family offers strong cation exchange, strong and weak anion exchange, and Protein A phases.

"Extend-C18 columns incorporate a unique patented bidentate silane, combined with a double-endcapping process that protects the silica from dissolution at high pH - up to pH 11.5. Columns are best applied for separations of compounds that are either (1) basic and have little or no retention at low or intermediate pHs, (2) more stable or more soluble at high pH, or (3) basic and show poor peak shape at low or intermediate pH.…

The ÄKTA ready™ 450 chromatography system is single use and has a  low flow rate and hold-up volume for efficient purification of small quantities in a GMP environment. 

The Axcend Focus LC® is a fully functional HPLC system built to deliver dependable, real-time data in a compact form factor.

Novel sample and data transfer network system

This new strong anion exchange resin offers an optimised macro-porous structure that ensures an efficient purification of large biomolecules, such as adeno-associated viruses (AAVs) and plasmid DNA (pDNA). With its high binding capacity for such molecules and high separation efficiency even at elevated flow rates, MacroSep IEX Q is a perfect addition to DSP platforms.

Bioinert coated YMC Accura BioPro IEX columns provide excellent peak shapes for sensitive compounds, ensuring high recovery from the very first injection.

YMC-Actus prepacked (semi-)preparative HPLC columns show high stability and long lifetimes even under high flow rates and steep gradient conditions without any void volume formation.

BioPro IEX, YMC's strong ion exchange material are based on a hydrophilic polymer which provides low non-specific adsorption and high recoveries. Porous and non-porous polymer beads are available for high loadability and throughput.  

YMC provides silica-based SEC phases with a dihydroxypropyl modification in 4 different pore sizes.

YMC-SEC MAB is a silica-based size exclusion chromatography column utilizing a dihydroxypropyl stationary phase bonded to a silica gel base, specifically designed for antibody separations.

BioPro HIC columns based on non-porous hydrophilic polymer beads and functionalised with butyl chains are optimised for the analysis of antibodies, antibody-drug conjugates (ADCs) and other proteins.

With YMC-Triart Prep, pH stable preparative HPLC stationary phases are available for industrial-scale applications. This hybrid silica-based material can be used in a pH range of 2.0 - 10.0 and allows more efficient cleaning procedures. The innovative YMC-Triart Prep combines mechanical strength and pH stability.

BioPro IEX and BioPro IEX SmartSep resins are specifically designed for biochromatography. They are available as a strong anion exchanger (BioPro IEX Q) and a strong cation exchanger (BioPro IEX S). The resins are based on a hydrophilic polymer matrix, with a particle size of 10 µm, 20 µm, 30 µm and 75 µm.

1 mm UHPLC columns are available in different lengths packed with the highly robust 1.9 µm YMC-Triart C18 particles.  

Bioinert YMC Accura Triart RP and HILIC columns are available for the analysis of critical substances including selected proteins, (oligo)nucleotides and metal-coordinating compounds such as organophosphates.

Highly robust hybrid silica material for the purification of proteins, peptides and oligonucleotides, which combines mechanical strength and pH stability. The larger pore size makes YMC Triart-Prep Bio200 C8 the ideal choice for the purification of mid-size to large biomolecules.

YMC-Triart columns are well-suited to a variety of applications in pharmaceutical and chemical laboratories.  Eight different phases are available, all trifunctionally bonded, in column sizes ranging from .075 – 300mm ID.

Specialized Columns for Mixed Polar and Nonpolar Compounds.

The Ultra line represents Restek’s broadest selection of stationary phases on a single silica support.Made of high-purity, type-B silica that minimizes activity and creates high-density bonding, the Ultra Amino Columns (USP L8) are designed for selective and reliable HPLC applications. Particle size: 3 μm or 5 μm, spherical Pore size: 100 Å Carbon load: 2% End-cap: no pH range: 2.5 to 8 Temperature limit: 80 °C USP phase code…

The Ultra line represents Restek’s broadest selection of stationary phases on a single silica support. Made of high-purity, type-B silica that minimizes activity and creates high-density bonding, the Ultra Cyano Columns (USP L10) are designed for selective and reliable HPLC applications.Particle size: 3 μm or 5 μm, spherical Pore size: 100 Å Carbon load: 8% End-cap: yes pH range: 2.5 to 8 Temperature limit: 80 °C USP phase co…