AdvanceBio RP-mAb
Agilent AdvanceBio RP-mAb columns are designed to optimize the performance of intact and reduced mAb analysis when analyzing monoclonal antibodies for biopharma discovery, development, and QA/QC applications
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Agilent AdvanceBio RP-mAb columns are designed to optimize the performance of intact and reduced mAb analysis when analyzing monoclonal antibodies for biopharma discovery, development, and QA/QC applications. Analysis of intact and reduced monoclonal antibodies are critical measurements for characterizing therapeutic proteins and understanding their efficacy and stability. Poor chromatographic separations can result in rework and even compromise the accuracy of the characterization. Based on Poroshell technology with unique engineering for pore size and bonded phases, AdvanceBio RP-mAb columns deliver higher resolution and faster run times to provide accurate, reproducible results. Available in a range of chemistries – SB-C8, C4, and diphenyl. View our full range of bioHPLC columns for your area of interest, get resources, and take advantage of special offers.
Features:
- Improved accuracy: Superficially porous particles (3.5 µm) with wide pores (450Å) increase mAb resolution while maintaining compatibility with all LC instruments
- Speed: Shorter analysis times compared to columns packed with fully porous particles of the same size
- Lower costs: The robust Poroshell packed bed and 2 µ inlet frit extend column lifetime by helping prevent inlet blockage
- Flexible method development: Range of chemistries - SB-C8, C4, and diphenyl
The LC handbook
This handbook from Agilent Technologies provides a practical introduction to liquid chromatography (LC), with a particular focus on reversed-phase high-performance liquid chromatography (HPLC). Designed as a reference guide for chromatographers of all experience levels, it covers the fundamentals of chromatography, column selection, packing materials, fittings, troubleshooting, and methods for improving productivity and analytical performance.
The guide aims to help users choose the most appropriate LC column for their application while addressing common challenges encountered during method development and routine analysis. The handbook also includes practical tips, application guidance, and troubleshooting advice to support work in analytical laboratories across industries including pharmaceuticals, environmental testing, food and beverage analysis, and chemical research.
Resource details:
- Resource type: Application notes
- Pages: 200
- Read time: 4 hours
Physicochemical characterization of coformulated monoclonal antibodies
This application note demonstrates the use of Agilent biopharma analytical tools, including cation-exchange chromatography (CEX), size exclusion chromatography (SEC), and peptide mapping, for the analysis of coformulated monoclonal antibodies (mAbs).
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