Drug discovery > Pre-Clinical Development Products & Reviews

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Products, services, reviews and techniques used in lead molecule delivery, formulation and toxicology, using assays and animal models.

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Lux3 BR brightfield live cell imager

Axion BioSystems

Lux3 BR is a small brightfield live-cell imager, equipped with a high-quality 6.4 MP CMOS camera. It is designed to work inside a standard cell culture incubator without disturbing temperature, airflow, and optimum culture conditions. Detailed brightfield images can be captured using the new device. In both x- and y-direction, 2072 pixels combined with 1.45 mm field of view provide a resolution of 0.7 µm/pixel. 

5.0/5.0
|1 Review
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Rotavapor® R-300

BUCHI

The new R-300 is the most innovative member of the industry leading Rotavapor® family. The award-winning rotary evaporator meets the highest standards in convenience and versatility. The modular design of Rotavapor® R-300 enables full integration of separate system components to create a rotavapor precisely tailored to individual needs. A central interface offers automated system control for the easiest and simplest instrument…

4.8/5.0
|24 Reviews
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Rotavapor® R-220 Pro: Industrial rotary evaporation

BUCHI

The Rotavapor R-220 Pro product line of 20L rotary evaporators includes four platforms to meet the challenging needs of scale-up and production laboratories: maximal flexibility with the widest range of glass assemblies, high performance for fastest distillation rates, continuous operation with automatic draining and refilling, and a cost-efficient model to cover essential needs.

4.7/5.0
|4 Reviews
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NucSpot Nuclear Stains

Biotium

Cell membrane-impermeant, nuclear-specific counterstains. Suitable for fixed cells or staining dead cells in live cultures. Available in a variety of colors from green to near-infrared (near-IR).

4.7/5.0
|6 Reviews


ZEISS ZEN 2011

ZEISS Research Microscopy Solutions

ZEN Shortens the Path to Your Goal ZEN 2011 Microsoft Software - ZEISS Efficient Navigation – is the single user interface you will see on all imaging systems from Carl Zeiss. The ZEN microscope software leads you simply and quickly to the result. At all times you see which options the system is making available to you and which step is appropriate to take next. Use ZEN imaging software to achieve scientific success: nothing d…

5.0/5.0
|1 Review
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ApoTox-Glo™ Triplex Assay

Promega Corp.

The ApoTox-Glo™ Triplex Assay combines three assay chemistries to easily assess viability, cytotoxicity and apoptosis events in the same cell-based assay well. First, viability and cytotoxicity are determined by measuring two differential protease biomarkers simultaneously with the addition of a single nonlytic reagent containing two peptide substrates. The live-cell protease activity is restricted to intact viable cells and i…

4.6/5.0
|3 Reviews
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Griess Reagent System

Promega Corp.

The Griess Reagent System measures nitrite (NO2–), which is one of two primary stable and nonvolatile breakdown products of nitric oxide (NO). Nitric oxide is an important physiological messenger and effector molecule in many biological systems, including immunological, neuronal and cardiovascular tissues. This assay relies on a diazotization reaction that was originally described by Griess in 1879. Through the years, many mod…

4.7/5.0
|1 Review
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ROS-Glo™ H2O2 Assay

Promega Corp.

The ROS-Glo™ H2O2 Assay is a homogeneous, fast and sensitive bioluminescent assay that measures the level of hydrogen peroxide (H2O2), a reactive oxygen species (ROS), directly in cell culture or in defined enzyme reactions.   This assay allows identification of conditions or test compounds, such as small molecule inhibitors or inducers, that alter ROS levels. The scalable multiwell format couples a stable luminescent si…

5.0/5.0
|2 Reviews
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CellTiter-Glo® Luminescent Cell Viability Assay

Promega Corp.

The CellTiter-Glo® Luminescent Cell Viability Assay(a,b) is a homogeneous method of determining the number of viable cells in culture based on quantitation of the ATP present, an indicator of metabolically active cells. The CellTiter-Glo® Assay is designed for use with multiwell formats, making it ideal for automated high-throughput screening (HTS), cell proliferation and cytotoxicity assays. The homogeneous assay procedure in…

4.7/5.0
|22 Reviews
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CellTiter-Glo® 2.0 Assay

Promega Corp.

The CellTiter-Glo® 2.0 Assay provides a homogeneous method for determining the number of viable cells in culture by measuring the amount of ATP present, which indicates the presence of metabolically active cells. The CellTiter-Glo® 2.0 Assay is based on the original CellTiter-Glo® Assay chemistry but with improved storage convenience for easy implementation. The CellTiter-Glo® 2.0 Assay is provided as a single, ready-to-use re…

4.9/5.0
|3 Reviews
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Lactate-Glo® Assay

Promega Corp.

The Lactate-Glo™ Assay is a bioluminescent assay for rapid, selective and sensitive detection of L-lactate in biological samples. Lactate is produced by glycolysis, a major metabolic pathway responsible for glucose homeostasis and energy production (1,2). Once considered merely a byproduct of glycolysis, lactate is now considered an important regulatory molecule of intermediate metabolism involved in cancer development, diabet…

5.0/5.0
|1 Review
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Digitonin

Promega Corp.

Digitonin can be used in cell viability and cytotoxicity assays. It is a detergent solution useful for permeabilizing cells and for creating a cytotoxicity chemistry positive control. Supplied at 20mg/ml in DMSO

5.0/5.0
|1 Review
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CellTiter 96® AQueous One Solution Cell Proliferation Assay (MTS)

Promega Corp.

The CellTiter 96® AQueous One Solution Cell Proliferation Assay is a colorimetric method for determining the number of viable cells in proliferation, cytotoxicity or chemosensitivity assays. The CellTiter 96® AQueous One Solution Reagent contains a tetrazolium compound [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt; MTS(a)] and an electron coupling reagent (phenazine ethos…

5.0/5.0
|2 Reviews
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GSH-Glo™ Glutathione Assay

Promega Corp.

The GSH-Glo™ Glutathione Assay is a luminescence-based assay for the detection and quantification of glutathione (GSH). The assay is based on the conversion of a luciferin derivative into luciferin in the presence of glutathione, catalyzed by glutathione S-transferase (GST). The signal generated in a coupled reaction with firefly luciferase is proportional to the amount of glutathione present in the sample. Luminescence is gen…

5.0/5.0
|3 Reviews
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