Drug discovery > Lead Discovery Products & Reviews

SkillPak 50 (2.5 cm ID x 10 cm L, CV 50 mL) and 200 (5 cm ID x 10 cm L, CV 200 mL) pre-packed columns offer a reproducible and efficient solution for developing purification methods for biomolecules. They are the best solution to scale up methods developed on SkillPak 1 and 5 mL pre-packed columns.

The TSKgel ODS-100 HPLC column features a newly developed RP material for the separation of small compounds which is specifically designed to simplify difficult separations.

The AptaFluor® SAH Methyltransferase Assay Kit enables ultra-sensitive, direct detection of SAH—the universal product of methyltransferase reactions—using a riboswitch-based TR-FRET format. With no coupling enzymes required, it delivers high signal-to-background, Z’ ≥ 0.7, and is fully HTS-compatible for drug discovery and inhibitor screening.

BellBrook Labs’ Lead Discovery Services deliver expert support for hit-to-lead efforts. From inhibitor screening and potency profiling to residence-time, mechanism-of-action, and selectivity studies, their team tailors efficient enzymatic assays to your program—accelerating lead advancement with precision and flexibility.

The Transcreener® cGAMP cGAS Assay Kit offers mix-and-read fluorescent detection of cGAMP—the product of cGAS activity—with no coupling enzymes required. Available in FP or TR‑FRET readouts (far-red tracers minimize interference), it’s HTS-ready (Z’ ≥ 0.7), automation-compatible, and validated on 96‑, 384‑, and 1536‑well formats for enzyme kinetics, SAR, and inhibitor screening.

The CD73 activity assay for HTS and hit-to-lead. Measure specific activity of CD73 in a simple mix-and-read format. The kit is designed for compound library screening and follow-up inhibitor discovery.

The Transcreener dAMP Exonuclease Assay directly measures dAMP produced by exonuclease enzymes as they cleave polynucleotides. 

Simplify your workflow and save valuable laboratory time with the fully automated MACS® Sampler, a perfect extension for the MACS® Matchmaker instrument, allowing you to fully integrate automatization solution for your interaction studies.

With the MACS® Matchmaker you can experience a robust platform that delivers quantitative data on binder affinity, kinetics, and specificity in complex samples. Unlock new possibilities in your research today – because every target deserves its perfect match!

PurePlus™ Deep Well Plates 96-well plates are designed for automation, high throughput screening (HTS), or heavy lab use. Each well holds either 1.2 mL or 2.2 mL and has smooth inside surfaces to ensure that all of your samples can be pipetted.

Syft Tracer Pharm11 redefines genotoxic impurities analysis for compliant pharma and CDMO workflows as fast and easy with no sample preparation. This solution includes next-gen SIFT-MS Syft Tracer, a CTC autosampler, a high-throughput (HTP) inlet, and 21 CFR Part 11 compliant software SyftAuditTracer.

Syft SafetySure is a class-leading solution for rapid, reliable detection of hazardous chemicals such as fumigants and volatile toxic industrial chemicals in workplace settings. It provides reproducible identification and quantification of hazardous chemicals commonly found in workplaces such as methyl bromide, sulfuryl fluoride, chloropicrin, ethylene dibromide, ethylene oxide and phosphine. It's simple to use with no consuma…

PCR Strip Capping Tool

Countable PCR is the only PCR-based method that directly counts your targets, giving you unprecedented and highly sensitive insights into your samples. Don't be limited by qPCR, dPCR, or even NGS. Find even the rarest targets when you experience single-molecule precision and ultra-high sensitivity in a familiar PCR workflow. Plus – quickly develop a new multiplex assay in 3 days.

In-depth understanding of complete genome in human, aninal, plant and microbe with end-to-end services.  

Sequencing only service for customer-premade libraries at different read lengths and capacities to suit any cost, project scale and turnaround with the world-leading, powerful, and sophisticated sequencing platforms (Illumina, Pacbio, and Oxford Nanopore). 

16S/18S/ITS rRNA amplicon metagenomic sequencing employs universal primers to target specific regions to identify the phylogeny and taxonomy from complex microbiomes.

Single cell RNA sequencing uncovers the complexity of cellular diversity to employ the study of unusual cell types, cell-lineage associations, and samples of heterogeneous nature with 10x Genomics technology.

Long Read Sequencing (LRS) service employs cutting-edge technologies such as Oxford Nanopore and PacBio platforms for decoding complex genomes, completing transcriptomes, exploring metagenomes, and investigating structural variations with unmatched precision.  

Whole exome sequencing allows for sequencing human and mouse exomes in an array of panel options, which facilitates research contexts and clinical contexts.

Flare™ is a ligand-based and structure-based drug design platform. Through high-resolution 3D visualization and in-depth analysis of target structures and potential ligands, Flare enables users to optimize and prioritize new molecules efficiently and effectively.

Flare™ enables the production of high-resolution 3D graphics of your ligands and proteins for publications and communication of results.

Flare™ FEP enables research chemists to refine docking results, making the right structure-based design choices for lead optimization with confidence.

Spark™ is a powerful scaffold hopping and bioisosteric replacement solution that generates highly innovative ideas for your project to explore chemical space and escape IP and toxicity traps.

Blaze™ is an advanced virtual screening platform enabling you to dramatically increase your wet screening hit rate at a fraction of the cost.