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Poly-L-Lysine Solution

Merck

Poly-L-Lysine is a synthetic amino acid chain that is positively charged having one hydrobromide per unit of Lysine. Poly-L-Lysine is widely used as a coating to enhance cell attachment and adhesion to both plasticware and glass surfaces. Certain cell types secrete proteases, which can digest Poly-L-Lysine. The molecular weight of Poly-L-Lysine for cell culture can vary significantly, with lower molecular weight (30,000 Da) b…

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BIOshell™ UHPLC and HPLC Columns

Merck

BIOshell™ HPLC and UHPLC columns deliver maximum speed and efficiency for the separation of biomolecules on both HPLC and UHPLC systems. The novel, superficially porous silica particles (SPP), with pore sizes from 90 Å up to 1000 Å, allow the separation of glycans as well as of very large proteins.

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HybridSPE®-Plus Plates

Merck

Our HybridSPE ® -PLus plates effectively remove phospholipids and proteins from biological matrices in a simple pass-through method for accurate and reproducible LC-MS analysis. Unlike other phospholipid removal SPE products on the market, the unique retention mechanism of HybridSPE ® allows for separation of even very hydrophobic analytes from phospholipid contaminants.     

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Supel™ Swift HLB SPE Cartridges

Merck

Supel™ Swift HLB is a polymeric stationary phase for solid phase extraction (SPE) prior to instrumental analysis. It has both hydrophilic and lipophilic functional groups for the extraction of a broad range of compounds from aqueous samples. It retains analytes having diff erent polarities and Log P values due to its hydrophilic and lipophilic balance (HLB) property.

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Fetal Bovine Serum

Merck

Fetal Bovine Serum (FBS) is the most widely-used growth supplement for cell culture, containing a complex mixture of biomolecules that includes growth factors, proteins, trace elements, vitamins and hormones for cell growth. Our extensive portfolio of FBS enables you to easily select the right FBS for your culture and criteria.

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ECMatrix

Merck

ECMatrix™ laminin substrates for culturing pluripotent stem cells (iPSCs) to promote in vivo–like morphology and simulate a more physiologically relevant environment for better intercellular interactions and better predictive cell models.

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Sigma-Aldrich® CRISPR synthetic gRNAs

Merck

Sigma-Aldrich ® one-part sgRNA and two-part crRNA:tracrRNA systems accelerate genome editing with Cas9 protein, mRNA, or established Cas9 expressing cell lines. Our guides are compatible with a variety of delivery methods including microinjection, electroporation, and lipofection.

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Immuno-Oncology Cell lines by Sigma-Aldrich®

Merck

Merck's immuno-oncology cell lines are innovative research tools for biologics discovery and clinical development. These are the perfect cell-based assay tools you need for the entire drug discovery and clinical development process. Whether you need screening tools for CAR/TCR therapies and mAB development, target cells for efficacy testing, or potency assays for clinical development, Merck provides functional biologically-re…

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MISSION® shRNA Clones

Merck

The largest and most validated shRNA collection from the RNAi consortium (TRC). Merck's unique shRNA formats leverage the discovery potential of the trusted and proven TRC shRNA collection. When you partner with them, you gain access to their world class lentiviral production expertise and the formats and specifications for RNAi knockdown experiments at any scale.

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CRISPRi Libraries, Pools, and gRNAs

Merck

Nuclease-independent applications of CRISPR provide equal targeting specificity but instead of cutting, CRISPRi allows for targeted interference of gene function by delivering transcriptional repressor domains to a specific target sequence using modified dCas9 + gRNA complexes. Gene knockdown is complementary to CRISPR-KO and CRISPRa (activation) and has distinct advantages over existing loss-of-function strategies like RNAi.…

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SeQuant® HILIC

Merck

SeQuant ® HILIC (hydrophilic interaction liquid chromatography) HPLC columns carry densely bonded, zwitterionic functional groups. These columns are available in a variety of lengths, particle sizes, and pore dimensions while showing an exceptional reproducibility and robustness.

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