Zetasizer Ultra by Malvern Panalytical

Manufacturer Malvern Panalytical  |  Available Worldwide
4.6
/
5.0
  |  13 reviews
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Zetasizer Ultra
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Average Rating: 4.6
13 Scientists have reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2021

  • Organization: Fluxus, Inc.



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    3 out of 5
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Easy to acquire data, analysis tools needs some improvements, great tech support.
Rating: 4.0

  • Application Area: Analyzing macromolecular and nanoparticle sizes and zeta potential

"The Zetasizer Ultra is a very useful instrument for our R&D activities as we can measure sizes of antibodies and other proteins, assess their aggregation status, and determine also approximate concentrations using the 3 angle measurement capabilities. We are also using the Zeta Potential technique to measure surface charges, mainly for nanoparticles and surface-modified nanoparticles. The system is robust and little instructions are needed for newcomers to DLS/ZP. The "Measure" menu is easy to use, but the data analysis is not well outlined. For example, one can only save ONE custom configuration of data displays, but each user has its own preferences and needs. The selection of the data display parameters and measurement conditions are not well accessible/presentable. Maybe it would be an advantage to be able to split graphs and tables into two different monitors for a better overview and quicker data analysis. Data transfer to a server or between two PCs is not user-friendly at all. Way too many steps, Malvern should find a better solution. The newest software version (V2.0+) does not run on our lap PC and so far nobody could resolve it. The Tech Support from Ulf Nobbmann is excellent, mostly available and feedback is always on the point. Malvern may consider offering the ZS Ultra with two laser wavelengths in the same instrument! We have troubles sometimes with fluorescently labeled species and strong fluorescence reaching the detectors - the filter in front of the BS detector is not sufficient to eliminate all fluorescence if strong emitters are investigated. Would be great to simply switch to laser wavelengths which is not exciting fluorophores. Although DLS/ZP measurements are very straightforward to do on the ZS Ultra, continuous education is needed to become proficient. The Malvern Materials Talks are of substantial help, similar webinars."

Review date: 22 Nov 2021 | Zetasizer Ultra
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: Illumina Singapore Pte Ltd



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Robust and simple to operate.
Rating: 4.7

  • Application Area:Sizing and zeta potential measurement

"The Zetasizer was a great addition to the analytical instrument available in our lab for sizing and zeta potential experiment. The software is self-intuitive and easy to operate. The customer service is top-notched and the care team will regularly check in on the status or any troubleshooting issues which we might have. Overall, it's a useful instrument to help us generate quick data (in several mins)."

Review date: 17 May 2021 | Zetasizer Ultra

Manufacturer's Response

Thanks for the review and glad to hear you are finding the system intuitive to use and our local distributors are supporting our customers well.
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: University of Padova



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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It is amazing, really easy to use and really useful results.
Rating: 5.0

  • Application Area:Analyze PLGA nanoparticles concentration

"It is a really amazing instrument and really easy to use, even for new students. I obtained really good results, better than the one obtained with the old instrument. It is really innovative."

Review date: 12 Mar 2021 | Zetasizer Ultra

Manufacturer's Response

Thanks you Greta for your review, nice to hear that our product is easy to use for your students too.
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: University of Padova



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Repeatable and reliable results in a short amount of time.
Rating: 4.7

  • Application Area:Measurement of size, PDI, zeta potential and concentration of lipid based nanoparticles

"After having the instrument in the laboratory, the technician thoroughly explained its use and functions and differences from Zetasizer nano which is the previous instrument we had in laboratory. I find the new Zetasizer very easy to use. It helps me to differentiate the different nanoparticle populations in my sample. Another good thing is that it has a filter for the fluorescent labeled nanoparticles."

Review date: 12 Mar 2021 | Zetasizer Ultra

Manufacturer's Response

Thanks for the review and glad to hear you are enjoying the new features.
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: Università degli Studi di Padova



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
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Easy to use instrument for sensitive analysis. Essential for a drug delivery lab!
Rating: 4.7

  • Application Area:Drug delivery; nanoparticle size and particle concentration; z-potential

"Zetasizer Ultra is a very easy-to-use instrument that allows for high reproducible measurements. The most amazing feature is the particle concentration analysis which permits to obtain with no much effort well-defined results. The after sales care is very careful and reliable."

Review date: 12 Mar 2021 | Zetasizer Ultra

Manufacturer's Response

Thanks for your review and happy to hear you are making good use of the particle concentration features.
  • Status:

    Advanced Reviewer

  • Member since: 2020

  • Organization: Brac University



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Greatly recommended for drug analysis!
Rating: 4.0

  • Application Area:Dynamic light scattering analysis

"Great results obtained for analysis of mean hydrodynamic particle size and zeta potential of aqueous suspended samples. The samples were suspended and the triplicate experiment yielded consistent results."

Review date: 09 Feb 2021 | Zetasizer Ultra

Manufacturer's Response

Thanks for taking time to review and we’re glad you are getting the results you need from your Zetasizer Ultra.
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: Becton Dickinson



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Excellent System!
Rating: 5.0

  • Application Area:Nanoparticle characterization

"This system is very user friendly compared to other particle sizers I have used previously. The method builder allows you to easily analyze several characteristics of our nanoparticles. I would highly recommend this product."

Review date: 15 Jan 2021 | Zetasizer Ultra

Manufacturer's Response

We are glad to hear that our new Zetasizer Ultra is user-friendly Lyndsay.
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: Instituto Politécnico da Guarda



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Can't work with nanotechnology without this instrument.
Rating: 5.0

  • Application Area:Analyze nanoparticles characteristics

"Super easy to use the product. The software is very simple, although they should add a standard values table for the materials instead the user has to search the values on literature. A super useful instrument for nanoparticle characterization."

Review date: 15 Jan 2021 | Zetasizer Ultra

Manufacturer's Response

Thank you Jorge for sharing such a positive review. We are glad to hear that our new Zetasizer is easy to use and perfect for nanoparticle characterization.
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: NanoMalaria Research Unit,Department of Pharmaceutics,Faculty of Pharmaceutical Sciences,Universit



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
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An excellent device for nano-characterization.
Rating: 4.7

  • Application Area:Characterization of solid nanoparticles

"Easy to use. Reproducible results. Convenient."

Review date: 08 Dec 2020 | Zetasizer Ultra

Manufacturer's Response

Thank you for the review Samuel, we hope your Zetasizer can help in your research on nanomedicines.
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: University of Groningen



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Easy to work with.
Rating: 5.0

  • Application Area:Polymer characterisation

"Easy to use and the software thinks along with the user."

Review date: 07 Dec 2020 | Zetasizer Ultra

Manufacturer's Response

Thanks for the review, we value your feedback and taking your time to provide it.


  • Status:

    Reviewer

  • Member since: 2020

  • Organization: CSL Behring



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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No complaints.
Rating: 4.3

  • Application Area:Particle size analysis

"No complaints - documentation for hourly qualification could be beefed up a little."

Review date: 12 Mar 2020 | Zetasizer Ultra

Manufacturer's Response

Reply, thanks for the review, however, we are a little bemused by the “hourly qualification” phrase could you contact us to explain further at https://www.malvernpanalytical.com/en/about-us/contact-us/? It’s not normally necessary to perform qualification at such a high frequency. Stay safe.
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Johnson Matthey



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Easy-to-use yet powerful instrument.
Rating: 5.0

  • Application Area:Raw material analysis for R&D

"The ZetaSizer Ultra is a dynamic, user-friendly instrument useful for a variety of applications. Malvern provides in-person training on the instrument and its theory that is very useful for newcomers to DLS and ELS measurements. There is a support team that consistently answers quickly with questions regarding interpreting data or other issues with the instrument. All and all a quality instrument and company to work with."

Review date: 18 Oct 2019 | Zetasizer Ultra

Manufacturer's Response

Andrew, thank you for the feedback – glad you are enjoying the new system.
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: MSR



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    5 out of 5
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Fantastic bit of equipment. Go for the Ultra not the Pro version.
Rating: 4.0

  • Application Area:Monitoring protein aggregation

"A very useful piece of equipment. representing good value for money. Had some zeta potential problems during first use but that was down to my sample preparation."

Review date: 18 Oct 2019 | Zetasizer Ultra

Manufacturer's Response

Many thanks for the feedback, if you have any particular feedback on our after sales support we would love to hear from you further.

The Zetasizer Ultra is the world’s most capable combined DLS and ELS system, incorporating Non-Invasive Back Scatter (NIBS®) and, uniquely, Multi-Angle Dynamic Light Scattering (MADLS) technology for the measurement of particle and molecular size. NIBS provides the versatility and sensitivity to measure over a wide concentration range, while MADLS permits a higher resolution view into your sample’s size distribution for those critical measurements.

An extension to MADLS affords the ability to directly analyze particle concentration. The measurement of particle concentration is calibration-free, suitable for a wide range of materials, requires no or little dilution, and is quick to use – all of which make it ideal as a screening technique.  This is a unique capability of the Zetasizer Ultra which can even be applied to samples such as viruses and VLPs, which were previously very challenging to measure. 

The Zetasizer Ultra also provides the highest sensitivity zeta potential and electrophoretic mobility measurements using M3-PALS technology.  Our affordable disposable folded capillary cells enable measurements in extremely low volumes, without direct sample-electrode contact, using our patented diffusion barrier method.  The information provided by these measurements is an excellent indicator of sample stability and/or propensity to aggregate.

The addition of Constant Current Mode for measuring electrophoretic mobility and zeta potential in high conductivity media reduces errors that can be associated with electrode polarization at higher ion concentrations.

Product Overview

Zetasizer Ultra by Malvern Panalytical product image

Zetasizer Ultra

Manufacturer Malvern Panalytical  |  Available Worldwide

4.6 / 5.0 | 13 reviews