Zetasizer Ultra by Malvern Panalytical

"The Zetasizer Ultra is a very useful instrument for our R&D activities as we can measure sizes of antibodies and other proteins, assess their aggregation status, and determine also approximate concentrations using the 3 angle measurement capabilities. We are also using the Zeta Potential technique to measure surface charges, mainly for nanoparticles and surface-modified nanoparticles. The system is robust and little instructions are needed for newcomers to DLS/ZP. The "Measure" menu is easy to use, but the data analysis is not well outlined. For example, one can only save ONE custom configuration of data displays, but each user has its own preferences and needs. The selection of the data display parameters and measurement conditions are not well accessible/presentable. Maybe it would be an advantage to be able to split graphs and tables into two different monitors for a better overview and quicker data analysis. Data transfer to a server or between two PCs is not user-friendly at all. Way too many steps, Malvern should find a better solution. The newest software version (V2.0+) does not run on our lap PC and so far nobody could resolve it. The Tech Support from Ulf Nobbmann is excellent, mostly available and feedback is always on the point. Malvern may consider offering the ZS Ultra with two laser wavelengths in the same instrument! We have troubles sometimes with fluorescently labeled species and strong fluorescence reaching the detectors - the filter in front of the BS detector is not sufficient to eliminate all fluorescence if strong emitters are investigated. Would be great to simply switch to laser wavelengths which is not exciting fluorophores. Although DLS/ZP measurements are very straightforward to do on the ZS Ultra, continuous education is needed to become proficient. The Malvern Materials Talks are of substantial help, similar webinars."

"The Zetasizer was a great addition to the analytical instrument available in our lab for sizing and zeta potential experiment. The software is self-intuitive and easy to operate. The customer service is top-notched and the care team will regularly check in on the status or any troubleshooting issues which we might have. Overall, it's a useful instrument to help us generate quick data (in several mins)."

"It is a really amazing instrument and really easy to use, even for new students. I obtained really good results, better than the one obtained with the old instrument. It is really innovative."

"After having the instrument in the laboratory, the technician thoroughly explained its use and functions and differences from Zetasizer nano which is the previous instrument we had in laboratory. I find the new Zetasizer very easy to use. It helps me to differentiate the different nanoparticle populations in my sample. Another good thing is that it has a filter for the fluorescent labeled nanoparticles."

"Zetasizer Ultra is a very easy-to-use instrument that allows for high reproducible measurements. The most amazing feature is the particle concentration analysis which permits to obtain with no much effort well-defined results. The after sales care is very careful and reliable."

"Great results obtained for analysis of mean hydrodynamic particle size and zeta potential of aqueous suspended samples. The samples were suspended and the triplicate experiment yielded consistent results."

"This system is very user friendly compared to other particle sizers I have used previously. The method builder allows you to easily analyze several characteristics of our nanoparticles. I would highly recommend this product."

"Super easy to use the product. The software is very simple, although they should add a standard values table for the materials instead the user has to search the values on literature. A super useful instrument for nanoparticle characterization."

"Easy to use. Reproducible results. Convenient."