Xevo G2-XS ToF

Waters® introduces DESI imaging for tissue identification and characterization in ovarian cancer research using the Xevo® G2-XS QTof mass spectrometer and lipidomic analysis. The use of DESI can help distinguish between several different tissue types in ovarian cancer samples during clinical research.

Characterization of extractables and leachables is essential for ensuring the safety, quality and efficacy of inhalation tobacco products, such as e-cigarettes. The testing of these products includes targeted screening (testing for known impurities) and non-targeted screening (testing for unknown impurities). The following poster presents the non-targeted screening of e-cigarettes for unknown impurities that may migrate from the starting materials, other packaging and device components using UPLC.

Metabolic phenotyping of clinical or animal studies for biomedical research relies on the generation of high quality, information rich data from which meaningful biological data can be derived. The following application note describes how the Waters Xevo G2 XS Mass Spectrometer is ideally suited to this task, employing very fast data acquisition rates without losing mass resolution and thus allowing for the retention of the fine chromatographic detail.

Diuretics are a class of pharmaceutical compounds whose primary aim is to promote urine production. They can also be used to mask the presence of banned or illegal substances by facilitating dilution of the urine and aiding excretion. Consequently the use of diuretics is prohibited for athletes by the World Anti-Doping Agency (WADA). However, a number of diuretics only ionise in negative electrospray mode (ESI-). This application note investigates methods to further extend the Forensic Toxicology Screening Application Solution with UNIFI to include compounds that ionise in negative mode and to use the method to determine the presence of diuretics in urine, particularly at concentrations below the WADA MRPL.

DESI imaging uses a charged jet of solvent to deposit micro-droplets onto a surface where analytes are extracted and desorbed into the gas phase at ambient pressure and temperature. This application note describes the DESI imaging technique as applied to mass spectrometry imaging using time-of-flight (TOF) mass spectrometers, such as the SYNAPT® G2-Si or the Xevo® G2-XS.

Waters®’ Quadrupole Time-of-Flight (Q-Tof™) mass spectrometers are fast, sensitive, high resolution, accurate mass instruments that integrate fully with fast separation techniques and are capable of generating the information scientists need to detect, identify, and quantify trace level compounds in complex and difficult samples. This white paper reviews the XS Collision Cell as the latest technological advance that delivers increased sensitivity and allows the Q-Tof to match the quantitative performance of many tandem quadrupole instruments without compromising mass resolution. The segmented nature of the quadrupole rods of the XS Collision Cell allows a DC gradient to be applied in order to draw ions through the device rapidly and enables fast switching between multiple MS/MS experiments.

Find out how scientists at the University of Toronto are using the Waters Xevo G2-XS QTof for the mass spec analysis of tumors.

Discover more in this poster.

Watch this video to learn how the Xevo G2-XS from Waters is essential in the highly sensitive screening of compounds leached from food packaging. Cristina Nerin, Professor of Analytical Chemistry at the University of Zaragoza, Spain, describes how she uses UPLC and the Xevo G2-XS to separate then detect unknown compounds at levels as low as 1ppb.

Learn about the use of QTOF technology for screening toxicology samples for designer drugs. In the absence of known targets, scientists must use non-targeted and semi-targeted screening methods to screen for drug fragments predicted from models of existing designer drugs.

Watch this video to discover how the TOF mass spectrometers from Waters have led to advances in proteomics and metabolomics at Colorado State University. Their robustness and speed allows for non-targeting metabolite identification which has transformed agricultural breeding approaches.

Watch this video to learn about Waters Full Spectrum Molecular Imaging System, which is the first to combine complementary MALDI, DESI and IMS capabilities.

For the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples the Xevo G2-XS QTof provides maximum robustness with no compromise in performance, high quantitative sensitivity, the highest quality, most comprehensive qualitative information, flexibility to adapt to changing needs and is accessible to experts and non-experts alike.

This video introduces the field of environmental forensics. Hear how mass spectrometry enables the low-level detection of compounds of interest to investigate the link between environmental exposure to compounds increase in human disease state. Interview filmed by SelectScience at ASMS 2014.

Prepare for the American Society for Mass Spectrometry(ASMS) Annual Meeting by discovering the many applications of mass spectrometry – from pesticide detection to imaging for cancer therapy

New techniques to detect illicit substances