Wyatt QELS™ Dynamic Light Scattering Module by Waters | Wyatt Technology

Manufacturer Waters | Wyatt Technology  |   Model: WIQ  |  Available Worldwide
  |  1 reviews
The Wyatt QELS™ module adds dynamic light scattering (DLS) capabilities to a DAWN™ , mini DAWN™ or µ DAWN™ MALS detector.

Wyatt QELS™ Dynamic Light Scattering Module by Waters | Wyatt Technology product image
Wyatt QELS™ Dynamic Light Scattering Module
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Average Rating: 5.0
1 Scientist has reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money

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    Expert Reviewer
  • Member since: 2015

  • Organization: Ajinomoto Althea

  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Exceptional sensitivity, very reliable!
Rating: 5.0

  • Application Area: In-line dynamic light scattering detection

"Having radius information on our biological samples is critical- and the QELS gives us just that. Working in conjunction with the HELEOS II and Optilab T-rEX, we measure molecular weight and hydrodynamic radius of all our biological samples efficiently and reliably. This is a must have add-on to your MALS detector!"

Review date: 20 Dec 2016 | Wyatt QELS™ Dynamic Light Scattering Module

The microDAWN™ is the only multi-angle light scattering (MALS) detector that can be coupled to any UHPLC-SEC system without loss of resolution. UHP-SEC-MALS determines absolute molecular weight, size and conformation of polymers, peptides, and proteins directly, without resorting to column calibration or reference standards.  


  • Sensitivity: 3.5 ng of 100 kDa polystyrene in THF or 70 ng of BSA in PBS, loaded on a 4.6 x 150 mm UHPLC-SEC column.  
  • Range of molar mass: 200 Da to 10 MDa (may vary with molecular composition, size or solvent)  
  • Range of rms radius R g : 10 nm to 50 nm  
  • Range of hydrodynamic radius: 0.5 nm to 30 nm (with optional Wyatt QELS™ embedded dynamic light scattering module)
  • Integrated ultrasonic flow cell cleaning module  
  • Software: ASTRA® chromatography software provides comprehensive analyses and user-friendly features including HPLC control, “One-click MW” and user-designed reports
  • Optional 21CFR11 support for GMP


  • Proteins: absolute molar mass, size and stoichiometry of monomers, oligomers, complexes, aggregates and fragments.
  • Glycoproteins, detergent-solubilized membrane proteins, PEGylated proteins, protein-polysaccharide and protein-DNA complexes; heme-containing proteins that absorb laser light
  • Protein-protein and protein-nucleic acid interactions
  • Polymers: absolute molar mass and size (distributions and moments), conformation, and branching
  • Linear or branched polymers, co-polymers
  • Most aqueous and organic solvents